Active material: Ibuprofen
When ATH: M01AE01
CCF: NSAIDs
When CSF: 05.01.01.06
Manufacturer: HEMOFARM A.D. (Serbia)
◊ Effervescent tablets white to yellowish white colors, round, Valium, bevelled on both sides, with a faint odor of lemon.
| 1 tab. | |
| ibuprofen D,L-lysinate | 342 mg, |
| that corresponds to the content of ibuprofen | 200 mg |
Excipients: sodium carbonate, povidone K-25, sodium saccharin, Aspartame, Xylitol, lemon flavor, simethicone water emulsion (Silfar SE-4).
10 PC. – тубы пластиковые (1) – пачки картонные.
10 PC. – тубы пластиковые (2) – пачки картонные.
20 PC. – тубы пластиковые (1) – пачки картонные.
20 PC. – тубы пластиковые (2) – пачки картонные.
◊ Pills, Film-coated white to yellowish-white, round, lenticular, with Valium on one side; на изломе – от белого до желтовато-белого цвета.
| 1 tab. | |
| Ibuprofen | 400 mg |
Excipients: microcrystalline cellulose PH101, sodium carboxymethyl, Colloidal anhydrous silica, stearic acid.
The composition of the coating film: a copolymer of methacrylic acid and ethacrylate (1:1), talc, Titanium dioxide (E171), polysorbate 80.
10 PC. – блистеры (1) – пачки картонные.
10 PC. – блистеры (2) – пачки картонные.
10 PC. – блистеры (3) – пачки картонные.
10 PC. – блистеры (5) – пачки картонные.
NSAIDs, phenylpropionic acid derivative. Anti-inflammatory, analgesic and antipyretic effect.
Механизм действия связан с угнетением активности ЦОГ – основного фермента метаболизма арахидоновой кислоты, is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Analgesic effect is due to both peripheral (indirectly, through inhibition of prostaglandin synthesis), and a central mechanism (mediated inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits platelet aggregation.
For external use anti-inflammatory and analgesic effect. Reduces morning stiffness, increases range of motion in the joints.
When administered ibuprofen almost completely absorbed from the gastrointestinal tract. Simultaneous food intake slows the rate of absorption. It is metabolized in the liver (90%). T1/2 is 2-3 no.
80% the dose is excreted in the urine mainly as metabolites (70%), 10% - Unchanged; 20% is output through the intestine as metabolites.
Inflammatory and degenerative diseases of joints and spine (incl. rheumatic and rheumatoid arthritis, ankiloziruyushtiy spondylitis, osteoarthritis), articular syndrome in exacerbation of gout, psoriaticheskiy arthritis, ankiloziruyushtiy spondylitis, Tendinitis, ʙursit, radiculitis, traumatic inflammation of soft tissue and musculoskeletal system. Neurology, mialgii, pain in infectious and inflammatory diseases of upper respiratory tract, adnexa, algomenorrhea, headache and toothache. Fever in infectious and inflammatory diseases.
Establish individually, depending on the nosology of the disease, clinical manifestations. When administered rectally or adult single dose of 200-800 mg, частота приема – 3-4 times / day; для детей – 20-40 mg / kg / day in divided doses.
External used for 2-3 weeks.
The maximum dose: для взрослых при приеме внутрь или ректально – 2.4 g.
From the digestive system: often - nausea, anorexia, vomiting, epigastric discomfort, diarrhea; may develop erosive and ulcerative lesions of the gastrointestinal tract; редко – кровотечения из ЖКТ; long-term use are possible liver dysfunction.
From the central and peripheral nervous system: often - headache, dizziness, sleep disorders, excitation, visual impairment.
From the hematopoietic system: long-term use may be anemia, thrombocytopenia, agranulocytosis.
From the urinary system: long-term use are possible renal dysfunction.
Allergic reactions: часто – кожная сыпь, angioedema; редко – асептический менингит (more frequently in patients with autoimmune diseases), bronhospastichesky syndrome.
Local reactions: when applied topically can dermahemia, tingling or burning sensation.
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, diseases of the optic nerve, “аспириновая триада”, violation of hematopoiesis, expressed by the human kidney and / or liver; Hypersensitivity to ibuprofen.
Do not use ibuprofen in the III trimester of pregnancy. Application in I and II trimesters of pregnancy is justified only in cases, the expected benefit to the mother outweighs the potential harm to the fetus.
Ibuprofen in small amounts excreted in breast milk. Use during lactation for pain and fever may. If necessary, long application or application at higher doses (more 800 mg / day) should decide the issue of termination of breastfeeding.
To use caution during concomitant liver and kidney diseases, chronic heart failure, when dyspeptic symptoms before treatment, immediately after surgery, When specifying a history of bleeding from the gastrointestinal tract and gastrointestinal diseases, allergic reactions, associated with taking NSAIDs.
During treatment requires systematic monitoring of the liver and kidneys, peripheral blood.
Do not apply topically to the affected areas of the skin.
With simultaneous use of ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemida, gipotiazida).
While the use of anticoagulants may increase their activities.
While the use of corticosteroids increases the risk of side effects from the gastrointestinal tract.
With simultaneous use of ibuprofen may displace from the compounds to plasma proteins indirect anticoagulants (acenocoumarol), hydantoin derivatives (phenytoin), oral hypoglycemic drugs sulfonylureas.
In an application with amlodipine may be a small reduction in the antihypertensive action of amlodipine; с ацетилсалициловой кислотой – уменьшается концентрация ибупрофена в плазме крови; с баклофеном – описан случай усиления токсического действия баклофена.
In an application with warfarin may increase bleeding time, also observed microhematuria, hematoma; с гидрохлоротиазидом – возможно небольшое уменьшение антигипертензивного действия гидрохлоротиазида; с каптоприлом – возможно уменьшение антигипертензивного действия каптоприла; с колестирамином – умеренно выраженное уменьшение абсорбции ибупрофена.
In an application with lithium carbonate, lithium increases the concentration in the blood plasma.
While the use of magnesium hydroxide increases the initial absorption of ibuprofen; с метотрексатом – повышается токсичность метотрексата.
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