Горичник - Peueedanum sand Waldts. and Kit.
Семейство Apiaceae (Umbelliferae) - Umbrella
Gorichnik – description of the plant
Perennial herb with a massive vertical root. Stems height of 20-150 / 200 cm, erect or lying, tight, branched at apex. Priosnovnye and lower leaves petiolate, pinnatilobate. Flowers - cyme 2-10 (14) the main beams, different lengths. Petals 5, almost round, bright yellow. Fruit shirokoэllipticheskiy, naked, grayish color; It is divided into two halves with three prominent ribbed projections; late fetal plenchatыmi otrostkami, both wings. It blooms from July to September.
Spread. It grows in dry, grassy and rocky areas. It is found in Central and Southern Europe.
Close view - Peucedanum officinale L.-лечебнй горячник (Семейство Apiaceae (Umbelliferae) - Umbrella). It occurs on dry and stony soils. Distributed in the same areas, as the previous view.
Raw materials - Roots and mature fruits.
The content of active substances in peucedanum
All organs of the plant contains coumarin (peucedanin, oksipeutsedanin et al.), essential oil. In some types of Peucedanum and flavonoids found piranokumariny.
The main effect of drug peucedanum
Vasodilatig.
Experimental and clinical data action peucedanum
Peucedanum arenarium - endemitnoe plant. Data in the literature on the effects of this plant is very small in relation to this kind of - almost no information. A significant contribution to the study of species and natural peucedanum coumarin have scientists, establish the presence of their properties vasodilatig.
Coumaric obtain total mix of roots peucedanum and three separate fractions. This herbal product after pharmacological studies undergoing clinical trials as a drug peukordyn.
Pharmacodynamics peukordina characterized by a specific action vasodilatig, which is much higher than the effect of a number of approved practice koronarodilatatorov. The experimental conditions peukordin increases coronary flow rate on isolated heart preparation blooded animal, and in terms of the whole organism. In cats, a dose 10 mg / kg m. t. peukordin increases koronarnyj debit from the coronary sinus 82 ± 11,4%, whereas prenylamine increases the flow rate at 58 ±6,7%. The effect lasts for 15-30 minutes. Along with the increase in coronary flow rate is set in the small difference rS02, 02 and pH of venous blood, zabrannoj from the coronary sinus, and arterial blood, taken from the carotid artery.
Peukordin also has positive inotropic and negative chronotropic action. In an experimental model in rabbits peukordin angina leads to a rapid cessation of hypoxic myocardial, and in most cases it prevents acute coronary artery disease. Peukordin also possesses antiarrhythmic effect, mounted on the model of arrhythmia induced by barium, but it is inactive against due to the introduction of aconitine arrhythmia and strophanthin.
Clinical trial peukordina in conditions of chronic coronary insufficiency, and for conditions after suffering a heart attack shows, the drug for a very short period of time improves the general condition, arresting more than 80% complaints of angina pectoris, and thereby makes it unnecessary to use Nitromintum. Observed patients indicate not only improved subjective measures, but also to a beneficial effect on a number of objective criteria after taking peukordina, thereby increasing possibilities capacitive infarction. Peukardin has no side effects.
Application peucedanum medicine
Up to now in clinical practice Peucedanum arenarium not applicable as a medicament. Rich coumarin mainly its roots. Bulgaria received the drug - a mixture of purified total coumarins, but still have a pharmaceutical preparation for practical application.
