Glycerol (When ATH A06AG04)

When ATH:
A06AG04

Characteristic.

Transparent, colorless syrupy very hygroscopic, odorless liquid, sweetness, neutral. Miscible in all proportions with water and ethanol, ethyl acetate (1:11), very bad — with ethyl ether (1:500), It is not mixed with benzene, xloroformom, tetrachloride, hydrogen, carbon disulfide and oils.

Pharmacological action.
Laxative, dehydrating, dermatoprotektivnoe.

Application.

Constipation different Genesis-functional, psychogenic, age (incl. rectal coprostasis people elderly), by limiting the mobility, pregnancy and breastfeeding, and others.; Prevention of constipation in patients, that can not strain during bowel movements, incl. in disease, thrombosed hemorrhoids, perianal abscess, anorectal stenosis, myocardial infarction; to soften the skin and mucous membranes processing (fluid).

Contraindications.

Hypersensitivity, renal failure, appendicitis, bleeding, diarrhea, hemorrhoids in the acute stage, fissure, inflammatory diseases and tumors of the rectum.

Restrictions apply.

Before oral or / use of glycerol as a dehydrating agent is necessary to compare the risks and benefits (considering the potential side effects) in patients with heart disease (dramatic increase in extracellular fluid can lead to heart failure), patients with fluid overload, diabetes, If the kidney function, elderly patients (increased risk of dehydration).

Side effects.

Prolonged local application: irritation and discomfort in the rectum; rarely is a catarrhal proctitis.

Cooperation.

When administered systemically potentiates the effects of diuretics, carbonic anhydrase inhibitors.

Overdose.

When administered systemically.

Symptoms: headache, dizziness, confusion, dry mouth or increased thirst, nausea, vomiting, diarrhea, severe dehydration, arrhythmia, renal failure.

Dosing and Administration.

Rectal, outwardly.

As a laxative: rectally (15-20 minutes after breakfast) one suppository 1 once a day. Treatment was stopped after the restoration of normal intestinal motility.

Outwardly: treated skin and mucous membranes solution for outdoor applications (84-88% Aqueous solution).

Cautions.

Regular use as a laxative is not recommended.

In the systemic application in dehydrated patients, as well as the presence of diabetes, It increases the risk of developing symptoms of severe dehydration, leading to vascular overload and, respectively, giperglikemii. Neketonovaya giperglikemicheskaya coma (oral use) there is seldom enough, However, it should be taken into account, that it has been several fatalities.