GISTAFEN

Active material: Sehifenadin
When ATH: R06AX
CCF: Gistaminovыh blocker H₁-receptors with 13ef7 rotoninova activity
ICD-10 codes (testimony): H10.1, J30.1, J30.3, L20.8, L23, L24, L28.0, L29, L50, T78.3
When CSF: 13.01.01.03
Manufacturer: OLINEFARM AS (Latvia)

Pharmaceutical form, composition and packaging

Pills white or nearly white, round, Valium, a facet and Valium.

	1 tab.
sehifenadin	50 mg

Excipients: lactose, microcrystalline cellulose, corn starch, calcium stearate, colloidal silicon dioxide.

10 PC. – упаковки ячейковые контурные (1) – пачки картонные.
10 PC. – упаковки ячейковые контурные (2) – пачки картонные.
10 PC. – упаковки ячейковые контурные (3) – пачки картонные.
10 PC. – упаковки ячейковые контурные (4) – пачки картонные.
10 PC. – упаковки ячейковые контурные (5) – пачки картонные.
10 PC. – флаконы полимерные (1) – пачки картонные.
20 PC. – флаконы полимерные (1) – пачки картонные.
30 PC. – флаконы полимерные (1) – пачки картонные.
40 PC. – флаконы полимерные (1) – пачки картонные.
50 PC. – флаконы полимерные (1) – пачки картонные.

Pharmacological action

Gistaminovыh blocker H₁-receptors with 13ef7 rotoninova activity. Moderate blocks serotoninove NT₁-receptors, weakening the action of neurotransmitters serotonin, histamines and allergies. Histamine causes the clinical manifestations of allergic inflammation: edema (increased capillary permeability), dermahemia (vasorelaxation), itchy skin and pain.

Feature of sehifenadina is, He has a protivogistaminnoe effect, not only blocking gistaminove n₁-receptors, and reducing histamine content in tissues by accelerating its destruction diamine.

Pharmacokinetics

Absorption

Sehifenadin rapidly absorbed from the digestive tract. C_max plasma levels achieved after 1-2 no.

Distribution

Predominantly accumulates in the lungs, liver; самая низкая концентрация – в головном мозге.

Metabolism

It is metabolized by oxidation, forming pharmacologically inactive metabolite.

Deduction

After taking a single dose of 50 mg T_1/2 is 12 no. After repeated doses of T_1/2 can be shortened to 5.8 no, ie. the drug is not koumouliruet in the body.

Excreted with jelchew 50% dose, с мочой – 20%. About 30% excreted unchanged, 40-50% - As metabolites.

Testimony

- Allergic rhinitis;

- Conjunctivitis;

- Hay fever;

- Urticaria;

- Angioedema;

- Pruritic dermatoses (incl. atopic dermatitis).

Dosage regimen

The drug is taken orally after a meal, drinking water.

Adults appoint 50-100 mg 2-3 times / day.

Typically, the therapeutic effect occurs within 3 days after initiation of treatment. The duration of therapy is 5-15 days.

Side effect

From the digestive system:

dry mouth, mild pain in epigastria, dyspepsia, increased appetite.

CNS: при применении препарата в высоких дозах – возбуждение, insomnia.

Other: редко – лейкопения, menstrual irregularities, increased urination, headache, drowsiness.

Contraindications

- Bronchial asthma;

- Simultaneous use of MAO inhibitors;

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

FROM caution You should use the drug in the human kidney (treatment starts with a minimum dose), liver.

Pregnancy and lactation

Use of the drug during pregnancy and lactation (breast-feeding) contraindicated.

Cautions

There are no clinical trials on the use of drugs in children and senile patients (more 70 years) age.

Sehifenadina pills can be combined with drugs for topical application (ointment, compresses, eye drops, nasal drops).

In most cases, drowsiness decreases or disappears through 2-5 day from the treatment beginning.

Effects on ability to drive vehicles and management mechanisms

Individuals, whose work requires quick emotional reactions (incl. transport drivers), during treatment should refrain from driving transport and activities potentially hazardous activities.

Overdose

Symptoms: dryness of mucous membranes, headache, vomiting, abdominal pain.

Treatment: simptomaticheskaya therapy. Antidote unknown.

Drug Interactions

Sehifenadin not do dampening effect of somniferous drugs and alcohol on the central nervous system, However, during the period of treatment should refrain from drinking alcohol.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children, dark place at a temperature no higher than 25 ° C. Shelf life - 2 year.