Hypersplenism – treatment of disease. Symptoms and prevention of diseases of Hypersplenism

Hypersplenism is a syndrome, characterized by a decrease in blood cell counts (leukopenia, thrombocytopenia, anemia) in patients with liver diseases, emerging gepatosplenomegaliej.

Гиперспленизм – Причины возникновения

Hypersplenism is more common in patients with chronic hepatitis, cirrhosis of the liver, diseases of accumulation, When granulematozah with increased spleen (sarkoidoz, limfogranulematoz), occur with portal hypertension syndrome.

Гиперспленизм – Симптомы

Hypersplenism is more common in patients with chronic hepatitis, cirrhosis of the liver, diseases of accumulation, When granulematozah with increased spleen (sarkoidoz, lPri this syndrome are more likely to develop leukopenia, which can reach largely (below 2000 in 1 ml of blood) and neutropenic limfocitopeniej or moderate thrombocytopenia. Anaemia in gipersplenizme, usually, type regenerator, with the anizocitozom of red blood cells (the preponderance of makrocitov in cirrhosis and hepatitis). The decrease in the number of cells in the peripheral blood is combined with bone marrow cells. Number of mielokariocitov in normal or moderately reduced. Increased number of jeritroblastnyh items, plasma and reticular cells, reduced number of myeloid element. Zitopenia amid gepatosplenomegalii is persistent in nature, However, when inflammatory complications can increase white blood cell count, Although Leukocytosis can be negligible. imfogranulematoz), occur with portal hypertension syndrome.

Гиперспленизм – Диагностика

An important place in the diagnosis of gipersplenizma is given to instrumental research methods: clinical analysis of blood, the study of bone marrow, needle liver biopsy, radionuclide and immunological research.

Гиперспленизм – Виды заболевания

Allocate primary hypersplenism, caused by hypertrophy village flailing about and eyeballs (the reason it is unclear), and secondary, occurs when some for bolevanijah.

Гиперспленизм – Действия пациента

When it detects signs of disease, consult a doctor.

Гиперспленизм – Лечение

In the treatment of gipersplenizma and hemolytic jaundice important prevention of infection, Sepsis, and when they occur — intensive treatment. Mikrosferocitarnaja hemolytic anemia (congenital gemolitiche skaya jaundice) It is a disease, inherited by autosomal dominant basis (in 20% patients with sporadic cases of illness Bo). Disease associated with defect structure of red blood cell membranes. The membrane becomes well permeable to sodium, which leads to an increase in osmotic pressure inside the erythrocyte, and he acquires spherical shape, becomes more brittle. Defective red blood cells are captured and subjected to rapid destruction of the splenic tka new, develops hemolytic anemia. There is also a view, that this form of anaemia spleen produces an excessive amount of auto-hemolysins. Due to overactive spleen and there is splenomegaly.

Гиперспленизм – Осложнения

Complications can be gipersplenizma sepsis, leukopenia (reduced number of lymphocytes), thrombocytopenia (the decrease in the number of platelets).

Гиперспленизм – Профилактика

Prevention gipersplenizma is the timely treatment of hepatitis and liver cirrhosis, as well as blood diseases.