Gepatrombin F

Active material: Heparin natriya, Polidocanol, Prednisolone
When ATH: C05AX03
CCF: The drug with antithrombotic, inflammatory and venoskleroziruyuschim action for local application in a proctology
Codes ICD-10 (testimony): I84, K60, L29.3
When CSF: 27.01.01.01.01
Manufacturer: HEMOFARM A.D. (Serbia)

Pharmaceutical form, composition and packaging

◊ Ointment for external application yellowish-white, translucent, gel, with a characteristic odor.

Excipients: solid paraffin, viscous paraffin, Nipple byezvodnyi, silicon dioxide.

20 g – aluminum tuba (1) Included with the tip – packs cardboard.

◊ Rectal Suppositories white, Conical; on the cut – white, Homogeneous.

Excipients: migliol 812, silicon dioxide, In Novato, gliceroltristearat.

5 PC. – package outline of PVC (2) – packs cardboard.

Pharmacological action

Combination drug with antithrombotic, inflammatory and venoskleroziruschim action for local application in a proctology.

Heparin – anticoagulant of direct action. When applied topically has a local anti-thrombotic, protivoekssudativnoe and mild anti-inflammatory effect; promotes regeneration of connective tissue; It prevents blood coagulation in hemorrhoids.

Prednisolone – GCS, anti-inflammatory, protivoekssudativnoe and anti-allergic effect, reduces itching, burning sensation, pain in the anorectal.

Lauromacrogol 400 (polidocanol) It has mestnoanesteziruyuschee effect and provides a hardening of hemorrhoids.

Pharmacokinetics

Heparin

Absorption and metabolism

After absorption biotransformed in the liver (partial liver enzyme heparinase) and in the reticuloendothelial system.

Distribution and excretion

Plasma protein binding is 95%.

V_d increases with increasing dose. Report the news. T_1/2 – 60-90 m.

Prednisolone

Absorption and metabolism

Prednisolone after absorption biotransformed in the liver.

Deduction

About 1% excreted in the urine as unchanged. Biology T_1/2 is 18-36 no, a T_1/2 plasma – 115-212 m.

Testimony

- External and internal hemorrhoids;

- Thrombophlebitis of veins of the anus;

- Svishti, eczema and itching in the anal area;

- Cracks anus.

Dosage regimen

Topically to the affected areas ointment applied thinly 2-4 times / day; after the disappearance of pain - 1 times / day for 7 days.

Rectal suppositories are administered 1-2 times / day after a bowel movement.

For the introduction of an ointment to the rectum using the screw on the tube tip, which is introduced into the rectum and lightly pressing the tube squeeze a small amount of ointment.

Side effect

Local reactions: allergic reactions, dermahemia.

With prolonged use and / or applied to the large surfaces are possible systemic side effects.

Contraindications

- Bacterial, Viral, fungal skin lesions;

- Tuberculosis;

- Syphilis;

- Skin tumors;

- Reaction to vaccination;

- Predisposition to bleeding;

- I trimester of pregnancy;

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated for use in the I trimester of pregnancy.

Cautions

When applied to a large amount of the drug to broken skin or mucous membranes marked slowdown in regeneration processes.

Overdose

Data on drug overdose Gepatrombin T is not provided.

Drug Interactions

Data on drug interactions drug Gepatrombin T is not provided.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, at a temperature from 15 ° to 25 ° C.. Shelf life - 3 year.