Hepa-Merz
Active material: L-ornithine L-aspartate
When ATH: A05BA
CCF: Gipoammoniemichesky drug
ICD-10 codes (testimony): K72, K73
When CSF: 11.16.05.02
Manufacturer: Merz Pharma GmbH & Co. KGaA (Germany)
PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING
◊ Granules for oral solution as a mixture of granules and orange white.
| 1 again. (5 g) | |
| L-ornithine L-aspartate | 3 g |
Excipients: Citric acid anhydrous, lemon flavor, orange flavor, sodium saccharin (saccharin sodium), sodium cyclamate, colorant sunset yellow, polyvinylpyrrolidone (povidone), fructose (levulose).
5 g – bags (10) – cardboard boxes.
5 g – bags (30) – cardboard boxes.
Pharmacological action
Gipoammoniemichesky drug. It reduces elevated levels of ammonia in the body, in particular, liver diseases. The operation is linked to its participation in the ornithine cycle of urea Krebs (formation of urea from ammonia).
It contributes to the development of insulin and growth hormone. It improves protein metabolism in diseases, requiring parenteral nutrition.
Pharmacokinetics
Ornithine aspartate dissociates into its components – aminokislotы ornithine and aspartate, are absorbed in the small intestine by active transport across the intestinal epithelium. Excreted in the urine through a cycle of urea.
Testimony
- Acute and chronic liver disease, accompanied by hyperammonemia;
- Hepatic encephalopathy (latent or expressed).
Dosage regimen
The drug is prescribed inside of 1 sachet of granules, dissolved in 200 ml of liquid, 2-3 times / day, postprandial.
Side effect
From the digestive system: in some cases – nausea, vomiting.
Other: allergic reactions.
Contraindications
- Severe renal insufficiency (sыvorotochnыy creatinine > 3 mg / 1 for);
- Lactation (breast-feeding);
- Hypersensitivity to the drug.
Pregnancy and lactation
The drug should be used with caution during pregnancy.
The drug is contraindicated during breast-feeding.
Cautions
In hepatic encephalopathy must be careful when driving and occupation of other potentially hazardous activities, require high concentration and speed of psychomotor reactions.
Overdose
Symptoms: increased severity of side effects.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
Drug Interactions
Drug Interactions drug Hepa-Merz is not described.
Conditions of supply of pharmacies
The drug is resolved to application as an agent Valium holidays.
Conditions and terms
The drug should be stored out of reach of children at or above 25 ° C. Shelf life – 5 years.
