Galantamin

When ATH:
N06DA04

Characteristic.

Gidroʙromid alkaloida, isolated from tubers snowdrop Voronova (Galanthus Woronowi A. The.), Family amarillisovыh (Amaryllidaceae). Contained also in other types of snowdrop sort Galanthus. The white crystalline powder bitter taste. It is soluble in water, practically insoluble in ethanol.

Pharmacological action.
Antiholinesteraznae.

Application.

Myasthenia, progressive muscular dystrophy, motor and sensory disorders in neuritis, polyneuritis, sciatica and radiculoneuritis, residual effects after cerebrovascular accident and brain damage infectious-inflammatory, toxic and traumatic nature (meningitis, meningoэncefalit, myelitis), psychogenic impotence and spinal, acute poliomyelitis (recovery period), cerebral palsy (spastic form), atony bowel and bladder, zakrыtougolynaya glaucoma, holinoliticheskimi poisoning drugs and morphine; functional X-ray diagnostics for diseases of the stomach and intestines.

Contraindications.

Hypersensitivity, epilepsy, hyperkinesis, bronchial asthma, angina, bradycardia, heart failure, arterial hypertension, Mechanical bowel obstruction, mechanical patency of the urinary tract.

Side effects.

Drooling, Sweating, nausea, vomiting, bradycardia, dizziness, arrhythmia, bronchospasm, muscle spasm bowel and bladder, convulsions.

Cooperation.

It is an antagonist of morphine and its structural analogs against inhibitory action on the respiratory center. Restores neuromuscular conductivity, blockaded kurarepodobnymi means antidepolyarizuyuschego action (tubocurarine et al.). It enhances the effect of depolarizing muscle relaxants (Ditilin). Holinoliticheskie funds (atropine, etc.) muskarinopodobnye eliminate peripheral effects of galantamine, kurarepodobne substance and ganglioblokatora — nikotinopodobnye.

Overdose.

Symptoms: increased severity of side effects.

Treatment: dose reduction, the use of anticholinergics (atropine, etc.).

Dosing and Administration.

P /, I /, percutaneously (by iontophoresis), inside (after meal). Dose picked individually, taking into account the patient's age, nature of the disease, efficacy and tolerability. Adults: n / a, on 2.5-10 mg 1-2 times a day, maximum single and daily dose 10 mg 20 mg respectively. Babies: n / a, 1-2 Times a day, at the age of 1-2 years are 0.25-0.5 mg, 3-5 years-0.5-1 mg, 6-8 years-0.75-2 mg, 9-11 years-1.25-3 mg, 12-14 years-1.75-5 mg, 15-16 years-2-7 mg. The course of treatment 10-30 days, if necessary, through repeated its 1-1.5 months.

In qualitative antagonist antidepolyarizuyushtih miorelaksantov: I /, incl. in combination with neostigmine methylsulfate, adult 15-20-25 mg, children 1-2 years-1-2 mg, 3-5 years-1.5-3 mg, 6-8 years is 2-5 mg, 9-11 years is 3-8 mg, 12-15 years-5-10 mg. In order to eliminate the residual neuromuscular blockade after repeated administration suksometoniya iodide (Ditilina) 20-35 mg in/in.

Cautions.

In case of violation of motor activity it is recommended to combine treatment with physiotherapy (massage, physiotherapy), who should start through 1-2 h after the introduction of galantamina.

Cooperation