Fusidic acid (When ATH D06AX01)

When ATH:


Fusidic (fusidic) acid is a natural antibiotic, produced by the fungus Fusidium scarlet, white crystalline powder, odorless or with a weak specific odor, practically insoluble in water, it is soluble in ether, hexane, soluble in acetone, pyridine, dioksane, slightly soluble in ethanol and chloroform.

Sodium fuzidat is white with a yellowish Sheen crystalline powder, soluble in water and ethanol, the molecular weight is 538,69.

Diethanolamine fuzidat — white or white with a yellowish white powder, easily soluble in water.

Pharmacological action.
Antibacterial, bacteriostatic.


Inside: disease, caused by susceptible microorganisms (incl. resistant to other antibiotics staphylococci) - Septicemia, pneumonia, otitis, infections of skin and soft tissue (furunculosis, pyoderma, sycosis, infected wounds, Burns et al.), osteomyelitis; gonorrhea, caused by resistant strains of gonorrhea benzylpenicillin, or hypersensitivity to penicillins patient.

B /: severe infectious and inflammatory diseases, caused by multidrug-resistant strains of staphylococci and other susceptible organisms (especially in patients with allergic reactions to penicillin and other antibiotics) - Pneumonia, sepsis, bacterial endocarditis, meningitis, osteomyelitis, purulent infections of soft tissue.

Locally: infections of skin and soft tissue, caused by susceptible microorganisms, incl. impetigo, boils, gidradenit, infected wounds, Sycosis beard, paronixija, folliculitis, carbuncles, erythrasma.

Konъyunktyvalno: bacterial eye infections, caused by susceptible microorganisms (conjunctivitis, .Aloe, barley, keratit, dakriocistit; infection, involving the removal of a foreign body from conjunctiva and cornea).


Hypersensitivity, hepatic failure, increased content of prothrombin in the blood (at / in the introduction of diethanolamine fusidate).

Restrictions apply.

Newborns, especially premature (the risk of bilirubin encephalopathy), abnormal liver function.

Pregnancy and breast-feeding.

During pregnancy and lactation is possible only in case of emergency, if the effect of therapy outweighs the potential risk to the fetus and child (It passes through the placenta, It passes into breast milk, displace bilirubin from binding to plasma proteins, thereby increasing the risk of kernicterus).

Side effects.

If ingestion: nausea, vomiting, diarrhea, abdominal pain (infants-regurgitation), allergic reactions (redness of the mucous membrane of the oral cavity and pharynx, pain when swallowing, skin rash and others.).

The on / in the introduction of diethanolamine fusidate: phlebitis and periphlebitis, allergic reactions (skin rashes, redness of the mucous membranes), gastrointestinal disorders (nausea, vomiting).

Locally: local irritating effect (redness and itching of the skin), allergic reactions.

Konъyunktyvalno: transient burning sensation, allergic reactions.


When combined with other antibiotics there is a significant potentiation of.

Dosing and Administration.

Inside, after meal. Under dose for adults is usually 0.5-1 g, daily-1.5-3 grams. Children — inside in the form of suspensions: at the rate of 20-80 mg/kg; the daily dose is divided into 3 admission. The duration of treatment depends on the nature of the disease and usually is 5-10 days, in the treatment of osteomyelitis is 2-3 weeks, if necessary - 3 more weeks.

Diethanolamine fusidate introduced Only / drip; speed of adults is 60-80 drops/min, children — 10-15 drops/min; daily dose for adults is 1,5 g, maximum daily - 2 g, daily dose for children 20-40 mg/kg; the daily dose is divided into 2-3 injection. After the end of infusions give/in struino 30-50 ml izotoniceski solution of sodium chloride or 5% glucose solution. Duration of treatment is 3-5 days (If necessary, and the absence of local irritants is to 7 days), then move on to oral treatment.

Locally (crme, gel or ointment): applied to the affected skin surface with a thin layer of 1-3 times a day after removal of pus and necrotic masses, in case of burns 2-3 times per week. The duration of treatment depends on the type and severity of the disease and is 7-14 days. The ointment can be applied under the bandage.

Konъyunktyvalno, in the affected eye instilled by 1 drop 2 once a day. After normalization of the eye treatment is continued 2 day.


In severe disease and the need for long-term treatment to prevent the development of resistance of pathogens and enhance the antibacterial activity is recommended to combine with benzylpenicillin, semisynthetic penicillins, rifampicin, Tetracycline.

When expressed complications, incl. in the development of allergic reactions (redness of the mucous membrane of the oral cavity and pharynx, pain when swallowing, skin rash and others.), drug overturned and conduct desensitizing therapy.

Diarrhoeal phenomenon caused by ingestion local irritant effect of the drug on the gastrointestinal mucosa; to prevent and reduce drug taking liquid food or milk.

When application of ointment to the skin around the eyes should be cautious, Given the possibility of irritating sodium fusidate the conjunctiva.

Before the appointment fuzidinu diethanolamine salt is necessary to determine the sensitivity of her abjection; the drug should be administered only in / in the drip. The solution is prepared time, dissolving 0,25 or 0,5 g in 25 or 50 ml of citrate-phosphate buffer, and then in an isotonic sodium chloride solution (for solution for children instead of isotonic sodium chloride solution used 10% glucose) to volume 250 or 500 ml; ready to drink the solution concentration should not exceed 2 mg / ml.

V / m injections are contraindicated because of the local irritant (possible necrosis).

When applying eye drops should not wear contact lenses. Since the drug is not obscures vision, restrictions on driving and operating machinery is not.


Active substanceDescription of interaction
GidrokortizonFMR. Reduces effect.
RitonavirFKV. Increases (mutually) plasma levels.
SaquinavirFKV. Increases (mutually) plasma levels.

Back to top button