Follitropin alfa

When ATH:
G03GA05

Characteristic.

White sterile powder, pyrogen.

Pharmacological action.
Estrogenpodobnoe.

Application.

Infertility, due to hypothalamic-pituitary dysfunction, accompanied by oligo- or amenorrhea (in combination with human chorionic gonadotropin); procedure superovulyatsii (fertilization in vitro and other reproductive technologies).

Contraindications.

Hypersensitivity, ovarian enlargement or ovarian cyst, not associated with polycystic ovary, gynecological bleeding of unknown cause, cancer âičnika, uterine or breast cancer, tumors of the hypothalamus or pituitary gland, the absence of the ovary, malformations of the sexual organs and tumors of the uterus, incompatible with pregnancy, obstruction of the fallopian tubes (possible development of an ectopic pregnancy), pregnancy, lactation.

Side effects.

Ovarian hyperstimulation syndrome: lower abdominal pain, nausea, vomiting, weight gain; increase or formation of ovarian cysts, ascites, gidrotoraks, thromboembolic events, fever and arthralgia, pain and redness at the injection site.

Dosing and Administration.

P /, / m (powder was dissolved in distilled water immediately before use; in 1 мл можно растворить до 450 ME, to reduce the volume administered). In anovulyatornom besplodii with sohranennыm menstrualynыm tsiklom treatment nachinayut in pervыe 7 days cycle. The course must be agreed with the individual response, determined by measuring follicle size by ultrasound and / or estrogen secretion. Ежедневная доза — 75–150 МЕ, при необходимости через 7–14 дней увеличивают на 37,5–75 МЕ. If after 5 Weeks absent a positive trend, the treatment is stopped. Через 24–48 ч после последней инъекции вводят однократную дозу ХГ — до 10000 ME. On the day of hCG injection and the next day it is recommended to have coitus. При проведении вспомогательных репродуктивных методик назначают ежедневно по 150–225 МЕ, 2-3 days starting on cycle, until a follicle of adequate (controlled by estrogen concentration in the serum and / or using ultrasound). Dose (maximum - 450 ME) adjusted in accordance with response to treatment. Through 24 ч после последней инъекции вводят однократную дозу человеческого ХГ — до 10000 ME, thereby inducing finally mature follicles.

Precautions.

Before treatment should be possible causes of infertility, gipotireoz, adrenocortical insufficiency, hyperprolactinemia, tumors of the pituitary gland and the hypothalamus.