Folacin
Active material: Folic acid
When ATH: B03BB01
CCF: Vitamin preparations
ICD-10 codes (testimony): D52, O99.0
When CSF: 17.01.01.01
Manufacturer: JADRAN Galenic Laboratory d.d. (Croatia)
PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING
◊ Pills Valium, yellow with a slight marbling, allowed to have inclusions orange, with a facet and Valium on one party, without smell.
| 1 tab. | |
| folic acid | 5 mg |
Excipients: lactose monohydrate, povidone, krospovydon, microcrystalline cellulose, magnesium stearate.
10 PC. – blisters (1) – packs cardboard.
10 PC. – blisters (2) – packs cardboard.
10 PC. – blisters (3) – packs cardboard.
Pharmacological action
Vitamin preparations. Folic acid in the body is converted to tetrahydrofolic acid, as a coenzyme, participates in various metabolic processes, and necessary for the normal maturation and education megaloblasts normoblasts. If folic acid deficiency develop megaloblastic type of hematopoiesis. The drug stimulates erythropoiesis, involved in the synthesis of amino acids (incl. methionine, serine, glycine), nucleic acid, purines, pyrimidines, in exchanging choline, gistidina. When pregnancy is protective against the teratogenic effects and the factors damaging the fruit. It promotes normal maturation and function of the placenta.
Pharmacokinetics
Absorption
After oral folic acid, connecting the stomach with intrinsic factor (specific glycoprotein), well and completely absorbed in the digestive tract. FROMmakh blood achieved through 30-60 m.
Distribution and metabolism
Almost completely bound to plasma proteins. Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid by the enzyme dihydrofolate reductase). Penetrates the GEB and placenta, excreted in breast milk.
Deduction
Excreted by the kidneys in unchanged form (if the received dose is much higher than the daily requirement), as well as metabolites. Displays by hemodialysis. 5 mg ingested folic acid excreted through 5 no.
Testimony
- Treatment and prevention of folate deficiency on the background of an unbalanced or malnutrition;
- Treatment and prevention of anemia of folate deficiency (makrotsitarnaya giperhromnaya anemia, anemia and leukopenia, drug induced and ionizing radiation, megaloblastnaya anemia, postrezektsionnaya anemia, sideroblastic anemia in elderly patients, anemia, associated with diseases of the small intestine, sprue syndrome and malʹabsorbcii);
- Treatment and prevention of anemia during pregnancy and lactation (breast-feeding);
- During pregnancy for the prevention of neural tube defects in the fetus;
- Long-term treatment of folic acid antagonists (methotrexate, combination sulyfametaksazol / trimethoprim), anticonvulsants (phenytoin, prymydon, phenobarbital).
Dosage regimen
The drug is prescribed inside.
To treatment of megaloblastic anemia, caused by folic acid deficiency, appoint 5 mg / day for 4 Months, to prevention – by 2.5 mg / day.
To prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and malnutrition or unbalanced – by 15 mg / day, Patients with the disease sprue – by 5-15 mg / day.
To prevention of fetal neural tube defects – by 2.5 mg / day for 4 weeks prior to pregnancy. The reception continued for I trimester of pregnancy.
Higher maintenance doses can be administered to patients with alcoholism, as well as patients with chronic infections and receiving anticonvulsants.
Side effect
From the digestive system: anorexia, nausea, abdominal distention, bitter taste in the mouth.
Allergic reactions: skin rashes, itch, эritema, bronchospasm.
Contraindications
- Pernitsioznaya anemia;
- Malignant neoplasms;
- Deficiency of cobalamin;
- Hypersensitivity to the drug.
Pregnancy and lactation
The drug is used according to indications during pregnancy and lactation (breast-feeding).
Cautions
Patients, on hemodialysis, require increased amounts of folic acid.
With prolonged use of folic acid, especially in high doses, may decrease blood concentration of vitamin B12 (цianokoʙalamina).
Long-term use of the drug should be combined with taking vitamin B12 (цianokoʙalamina).
Overdose
Data on overdose are not given folacin.
Drug Interactions
In an application with chloramphenicol, neomycin, polymyxins, tetracyclines the absorption of folic acid reduced.
With simultaneous use of folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine, glutetimid, methotrexate, phenytoin, pyrimidine, chloramphenicol.
The use of folic acid may reduce the plasma levels of phenobarbital, phenytoin and primidone, and cause an epileptic seizure.
Decrease or change in absorption can occur, while the use of folic acid and cholestyramine, so, Folic acid should be taken 1 hours before or after 4-6 hours after taking cholestyramine.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
The drug should be stored out of reach of children at or above 25 ° C. Shelf life – 5 years.
