Physico-chemical interactions of drugs

By physico-chemical interactions are the processes, leading to changes in the state of aggregation, and other physicochemical properties of the drug (without any change of chemical characteristics), as a result there are difficulties in the preparation or use of drugs.

In many cases, Using rational technological methods, pharmacist possible to prevent these processes in the preparation of medicines. For Example, processes dampness avoided by selecting the package or equipping medication appropriate inscription with the conditions of storage. Replacing one another solvent, or to change the number of, You can prevent the separation of the drug, or to improve the conditions of dissolution (mixing) its constituent components. Cases of selected irrational formulations are rare and only among the extemporaneous compounding.

Where, when to avoid the phenomenon of incompatibility of components is not possible, a formulation referred to the category of irrational,

This group should also include chemical incompatibility - Compositions, in which the flow of various intensities chemical reactions to form products, not suitable for use in therapy. The formation of these products can also be combined in step storing drugs, in violation of conditions (regimes) store, provided legal and technical documentation.

Finally, pharmaceutical interactions should include processes, которые имеют место в комбинированной терапии при введении нескольких растворов в форме инъекции в одной инфузионной системе (Syringes) или между лекарственным веществом и растворителем, when there is an interaction of the mixture components, resulting in unsuitability of their use in medical practice.