FITOZID

Active material: Etoposide
When ATH: L01CB01
CCF: Anticancer drug
When CSF: 22.03.01
Manufacturer: DABUR PHARMA LIMITED (India)

Pharmaceutical form, composition and packaging

Concentrate for solution for infusion as a clear, from almost colorless to pale yellow solution.

Excipients: macrogol 300 (polyethylene glycol 300), benzyl alcohol, ethanol, polysorbate 80, lemon acid, sodium citrate.

5 мл – флаконы бесцветного стекла (1) – пачки картонные.

Pharmacological action

Фармакологическое действие – противоопухолевое. It affects the late S and G2 phase of the cell division. It interacts with the cellular microtubules and inhibits topoisomerase A2 and DNA synthesis. When kontsentrauii 10 g / ml binds to plasma proteins about 90%. After intravenous administration, the kinetics of the drug is described a two-phase model with a half-life in 1 phase average 1,5 часа и во вторую – 4-11 hours. Not accumulates in the appointment for 5 day dose 100 mg / m2. It crosses the placenta and the blood-brain barrier. Enters the brain tumor tissue faster, than healthy brain tissue. Excreted by the kidneys in an unchanged form and in the form of metabolites (40-60% – в течение 48-72 hours), с калом – менее 16% during 72 hours.

Indications

Small cell lung cancer, testicular cancer, khorionkartsinoma, sarkoma Juinga, Kaposi's sarcoma, sympathicoblastoma, raʙdomiosarkoma, mammary cancer, non-Hodgkin's lymphoma, limfogranulematoz, Acute leukemia myeloydnыy.

Contraindications

Hypersensitivity, neutropenia, thrombocytopenia, the liver and kidneys, pregnancy.

Side effect

Inhibition of hematopoiesis, nyekrotichyeskaya entyeropatiya, toxic hepatitis, aretrialnaya hypotension (With rapid intravenous), cardiac dysfunction. Редко – поражения ЦНС, obratimaya alopecia, phlebitis at the injection site, allergic reactions.

Cooperation

The combined use with other cytotoxic drugs increases the risk of myelosuppression.

Overdose

No information.

Cautions

Treatment should be a doctor, with experience of chemotherapy, and if the conditions, needed for the relief of complications of treatment (sterilynыy box, sufficient arsenal of antibiotics, the possibility of substitution therapy with blood components).