FERROVYR

Active material: deoxyribonucleat complex sodium iron
When ATH: J05AX
CCF: The antiviral and immunomodulatory drugs
ICD-10 codes (testimony): A60, A84, B00, B02, B18.2, B20, B24
At KFU: 09.01.05.03
Manufacturer: TEHNOMEDSERVIS ZAO FP (Russia)

Pharmaceutical form, composition and packaging

The solution for the / m 15 mg / ml clear, yellow color, without foreign impurities.

2 ml – bottles (5) – packings Valium planimetric (1) – packs cardboard.

The solution for the / m 15 mg / ml clear, yellow color, without foreign impurities.

5 ml – bottles (5) – packings Valium planimetric (1) – packs cardboard.

Pharmacological action

The antiviral drug with a strong immunomodulatory effect of natural origin. It is a purified standardized deoxyribonucleat sodium salt complex with iron.

Exhibit antiviral action against RNA- and DNA viruses. The drug activates the antiviral, antifungal and antimicrobial immunity.

In exchange application Ferrovir in the complex therapy of HIV infection observed increase in CD4 lymphocytes in the blood (It persists for 1-1.5 months after the end of treatment). Simultaneously decreasing the viral load in the body, expressed in the reduction of HIV RNA level compared to baseline.

When recurrent herpes infection recurrence and shortened developing long-term remission after a 10-day treatment kursovovgo.

Application for chronic hepatitis C leads to a decrease in the replicative activity of the hepatitis C virus, and puts the process in a latent phase of the restoration of liver cells and the absence of viral replication, improves tolerability (decrease nausea, dizziness).

The product is characterized by a high degree of activity in the joint presence of viruses and the main opportunistic diseases.

Pharmacokinetics

Absorption

When i / m administration is rapidly absorbed into the blood. The time to reach C_max – 0.5 no.

Distribution

Through 0.5 h the concentration of drug in the blood is reduced in connection with its distribution in the organs and tissues. Distributed in organs and tissues via endolymphatic transportation way; It has a high affinity for bodies of the hematopoietic system; It has been actively involved in cellular metabolism, embedding into cell structures. During the course of daily use of the property has cumulated in organs and tissues.

Deduction

T_1/2 – 36 no. The average retention time of the drug in tissues and organs – 72 no. Excreted unaltered in the form of metabolites, preferably with urine and partially – with feces.

Testimony

Ferrovir used in a combination therapy:

- Chronic hepatitis C;

- Herpes;

- Tick-borne encephalitis;

- Viral opportunistic infections in HIV-positive patients;

- HIV-positive patients and AIDS patients;

- HIV-infected patients with hepatitis C;

- HIV-infected patients with recurrent herpes infection.

Dosage regimen

Adults at treatment of HIV infection or AIDS the drug is prescribed in / m 5 ml 2 times / day for 14 days. Subsequent courses – on indications.

At the treatment of herpes infections – w / m 5 ml 1-2 times / day for 10 days.

At treating hepatitis C. – w / m 5 ml 2 times / day for 14 days. In the following 14 days – in the same daily dose every other day.

At treatment of tick-borne encephalitis – by 5 ml 2 times / day for 5-10 days.

Side effect

Maybe: temperature rise, hyperemia, moderate pain at the injection site.

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

- Children's age;

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

To reduce pain medication should be administered / m slowly over 1-2 m.

In / in the introduction of the drug is not permitted.

Clinical trials allow us to recommend the use of the drug in the treatment of Ferrovir cytomegalovirus infection, generalized herpes infection, Genital herpes, HPV infection, when combined forms of HIV with hepatitis C, CMV and HSV.

According to clinical studies proven effective in combination, and in monotherapy HSV infection after a single intraperitoneal injection daily for 10 days. In the treatment of human papillomavirus infection – by 5 ml 1 time / day / m intervals 72 no. In the treatment of cytomegalovirus infection – by 5 ml 1-2 times / day for 10 days.

Overdose

Currently, cases of drug overdose were reported Ferrovir.

Drug Interactions

The drug is moderately potentiates the effect of anticoagulants, hepatoprotectors. When used in combination therapy reduces the toxicity and adverse effects of the drugs at the same time (headache, nausea).

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored in a dark place at a temperature of 4 ° to 20 ° C. Shelf life – 5 years.

The solution for injection should be used immediately after opening the bottle; Do not store opened vials.