Etifoxine

When ATH:
N05BX03

Pharmacological action

Anxiolytics (tranquillizer). Benzoxazine derivative, It has anxiolytic activity, less sedative effect. Selectively affects chloride channels supramolecular GABA-benzodiazepine receptor complex hlorionofor, activating GABAergic transmission.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, TCmax - 2-3. It is metabolized in the liver to form several metabolites, one of which, dietiletifoksin, It is active. It penetrates through the placental barrier. T1 / 2 etifoxine - 6 no, dietiletifoksina - 20 no. Report the news (in the form of metabolites and intact) and intestines.

Testimony

Alarm, fear, internal stress, irritability, depressed mood (incl. against the background of systemic diseases of cardiovascular nature).

Contraindications

Hypersensitivity, shock, myasthenia, severe liver failure, CRF, Simultaneous reception of ethanol, pregnancy, lactation, childhood (to 18 years). For LF, containing lactose (additionally): galactosemia, malabsorption of glucose and galactose, lactase deficiency.

Dosage regimen

Inside, with a little water, by 50 mg 3 times a day, or 100 mg 2 once a day. The course of treatment for a few days to 4-6 weeks.

If you missed doses should not double the dose during the subsequent acceptance.

Side effect

Hives, angioedema, skin rash, drowsiness (in the early days of admission).

Overdose

Symptoms: slackness, hypersomnia.

Treatment: symptomatic; gastric lavage.

Drug Interactions

It enhances the effect of opioid analgesics, ʙarʙituratov, hypnotics, antihistamine drugs, neuroleptics, etc.. PM CNS depressants.

It enhances the effect of ethanol.

Cautions

In the period of treatment should refrain from driving and Occupation potentially hazardous activities, require high concentration and speed of psychomotor reactions.