Estsin

When ATH:
C05CX

Pharmacological action

Triterpene glycosides (saponin) from fruits (seed) horse chestnut (sodium salt). It has expressed kapillyaroprotektivnoy activity, has antiexudative action.

Pharmacokinetics

Once inside 50 mg extract of horse chestnut C_max plasma levels achieved after 2.35 h and is 25.31 ng / ml.

Plasma protein binding is 84%.

T_1/2 is 19.87 no. Once inside 0.11% extract of horse chestnut excreted by the kidneys in the form of escin.

Testimony

Post-thrombotic syndrome and some symptoms of chronic venous insufficiency of various etiologies (incl. swelling, cramps in the calf muscles, pain and a feeling of heaviness in the legs), phlebeurysm, trophic disorders. Post-traumatic or post-operative swelling of the soft tissues.

Dosage regimen

В/в взрослым – 5-10 mg / day, children under the age of 3 years - 100 ug / kg / day, from 3 to 10 years - 200 ug / kg / day.

Oral dosage depends on the dosage form and determined individually.

For external use gently rubbed into the affected area several times a day.

Side effect

Allergic reactions: skin rash, hives, angioedema, anaphylactic shock, fever.

From the digestive system: dyspepsia, nausea.

Contraindications

Renal failure, I trimester of pregnancy, Hypersensitivity to Escin.

Pregnancy and lactation

Escin contraindicated for use in the I trimester of pregnancy. Can be used in the III trimester of pregnancy, particularly when a swelling of the lower limbs and the absence of nephropathy.

Not recommended during lactation (breast-feeding).

Cautions

During treatment, should periodically monitor renal function.

Drug Interactions

The on / in the introduction estsina women, receiving hormonal contraceptives, the dose should be doubled solvent.

While the use of escin may increase nephrotoxicity of aminoglycoside antibiotics.

While the use of escin may increase the activity of anticoagulants and other drugs with antithrombotic action.

With simultaneous use of cephalosporins displace escin from bonds to plasma proteins.