JeMOSINT

Active material: Desmopressin
When ATH: H01BA02
CCF: Vasopressin analog. Antidiarrheal
ICD-10 codes (testimony): D66, D68.0, Z51.4
When CSF: 15.06.03
Manufacturer: KEDRION S.p.A. (Italy)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Solution for injection clear, colorless, without visible mechanical inclusions.

Excipients: sodium chloride, xlorʙutanol, hydrochloric acid 0.1 m, water d / and.

0.5 ml – colorless glass vials (5) – pallets (2) – packs cardboard.

Solution for injection clear, colorless, without visible mechanical inclusions.

Excipients: sodium chloride, xlorʙutanol, hydrochloric acid 0.1 m, water d / and.

1 ml – colorless glass vials (5) – pallets (2) – packs cardboard.

* international non-proprietary name, recommended by the WHO – dezmopressin.

Pharmacological action

Hemostatic drug. Synthetic analogue 8-arginine vasopressin, has the properties of natural antidiuretic hormone.

Gemostaticescoe effect due to the ability to raise desmopressina concentration in plasma coagulation factor VIII, to promote the release of plasminogen activator in blood.

Pharmacokinetics

The farmakokinetike drug Jemosint not available.

Testimony

is hemophilia a (light and moderate forms);

— von Willebrand Disease Type I;

— the preoperativive preparation and postoperative patients with von Willebrand disease;

-preparation of patients uremyei, with extended bleeding time, to invasive manipulation.

Dosage regimen

Jemosint appointed dose 0.3 µg/kg body weight/day.

Jemosint you can enter n/a or/in the drip, tentatively rastvoriv physiological solution (birth weight less than 10 kg it is recommended to use 10 ml saline, body weight more 10 kg – 50 ml saline). In/in the drug is injected slowly, during 15-30 m. Re-introduction of the preparation is possible no earlier than 48 no.

Side effect

Cardio-vascular system: transient headache; seldom-hyperemia, puffiness, increased blood pressure, slight decrease ad, with the corresponding increase in HEART RATE, thrombosis.

From the digestive system: nausea, moderate abdominal pain.

From the water-electrolyte metabolism: rarely – gipergidratatsiya, giponatriemiya.

Allergic reactions: in a few cases – anaphylactic reactions.

Other: moderately expressed pain in vagina; rarely – burning at the injection site.

Contraindications

— von Willebrand disease type II;

-inhibitory form of hemophilia a;

is hemophilia in;

- Arterial hypertension;

- Chronic nephritis;

- Anurija;

- Edematous syndrome of various genesis;

- Congestive heart failure;

- Hypersensitivity to the drug.

Pregnancy and lactation

The safety of the drug Jemosint in pregnancy and lactation has not been established, Therefore it is only possible, If the expected benefit to the mother outweighs the potential risk to the fetus and infant.

Cautions

Jemosint should be administered with caution in bronchial asthma, with a history of epilepsy, migraine, the inclination to trombozam.

When using Emosinta necessary to control the amount of fluids you drink, particularly in the young and elderly patients, to avoid overhydration and hyponatremia.

When applied as necessary to control Emosinta diuresis, tk. thanks antidiuretic effect of the drug may delay the fluid in the body.

Re-introduction of the drug in less than 48 h could reduce its effectiveness.

The drug is effective in activity of coagulation factor VIII more 5%, It is therefore necessary to monitor the level of clotting factor VIII in the blood.

The on/in the introduction should monitor HR.

Effects on ability to drive vehicles and management mechanisms

Jemosint has no effect on the ability to manage road and mechanisms.

Overdose

Symptoms: increasing incidence of side effects.

Treatment: No specific antidote. In case of overdose you must hold a correction dose or to suspend its application.

Drug Interactions

If you are applying to Jemosinta with hlorpropamidom, clofibrate, There is an increasing indomethacin antidiuretic action; together with the application glibutidom, carbamazepine is weakening.

Potenziruet Jemosint hypertensive medications.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored in a dark place at a temperature between 2° c to 8° c. Shelf life - 2 year.