Effered tablets are slippery: instructions for using the medicine, structure, Contraindications

Active material: paracetamol
When ATH: N02BE01
CCF: Analgesic-antipyretic
ICD-10 codes (testimony): G43, J06.9, J10, K08.8, M79.1, M79.2, N94.4, N94.5, R50, R51, R52.0, R52.2
When CSF: 03.02.01.01
Manufacturer: BRISTOL-MYERS SQUIBB (France)

Effered tablets are slippery: dosage form, composition and packaging

◊ Effervescent tablets white, round, flat, with beveled edges and a notch on one side; when dissolved in water is observed intense effervescence.

Excipients: Citric acid anhydrous, anhydrous sodium carbonate,, natriya carbonate, sorbitol, soluble saccharin, docusate sodium, povidone, Sodium benzoate.

4 PC. – strips (4) – packs cardboard.

Effered tablets are slippery: pharmachologic effect

Analgesic-antipyretic. It has analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, acting on pain centers and thermoregulation. In inflamed tissues cellular peroxidase neutralize the effect of paracetamol on COX, which explains the almost complete absence of his anti-inflammatory effect.

It has no negative impact on the water-salt metabolism (sodium and water retention) and gastrointestinal mucosa due to lack of effect on prostaglandin synthesis in peripheral tissues. The possibility of formation of methemoglobin is unlikely.

Effered tablets are slippery: pharmacokinetics

The data on the pharmacokinetics of the drug in tablet form Efferalgan effervescent not provided.

Effered tablets are slippery: testimony

• pain syndrome of mild or moderate intensity: headache, toothache, migraine, neuralgia, myalgia, back pain, pain in trauma and burns, sore throat, algomenorrhea;
• elevated body temperature with colds and other infectious and inflammatory diseases.

Effered tablets are slippery: dosing regimen

The tablet should be dissolved in a glass of water (200 ml) and drink.

Assign inside of 0.5-1 g (1-2 tab.) 2-3 times / day at intervals of at least 4 no.

The maximum single dose is 1 g (2 tab.), daily – 4 g (8 tab.).

In patients with impaired liver or kidney function and elderly patients the daily dose should be reduced, interval between doses of the drug should be at least 8 no.

Length of treatment (without consulting your doctor) is less than 5 days, when used as an analgesic agent and 3 day – as an antipyretic.

Effered tablets are slippery: side effects

Allergic reactions: sometimes – skin rash, itching, angioedema.

From the hematopoietic system: rarely – anemia, thrombocytopenia, metgemoglobinemiâ.

Other: long-term use at doses, greatly exceeding the recommended, It increases the likelihood of the liver and kidneys (necessary to monitor patterns of peripheral blood).

The drug was well tolerated at recommended doses.

Effered tablets are slippery: Contraindications

• Saint Martin's evil;
• deficiency of glucose-6-fosfatdegidrogenazы;
• I and III trimesters of pregnancy;
• lactation (breast-feeding);
• Children up to age 15 years (weight less 50 kg);
• hypersensitivity to the drug.

FROM caution use in patients with renal and / or hepatic insufficiency, congenital hyperbilirubinemia (Gilbert syndrome, Dubinin-Johnson and Rotor), viral gepatite, alcoholic liver disease, in elderly patients.

Effered tablets are slippery: Pregnancy and lactation

Do not use this drug in I and III trimesters of pregnancy and lactation (breast-feeding).

Effered tablets are slippery: Special instructions

With continued feverish syndrome, during treatment with paracetamol more 3 days, and pain syndrome – more 5 days, requires medical consultation.

Distorts the figures of laboratory tests for the quantitative determination of uric acid in plasma.

To avoid liver toxicity of paracetamol should not be combined with alcoholic drinks, and to take persons, prone to chronic alcohol consumption.

The risk of liver damage increases in patients with alcoholic hepatosis.

Prolonged use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.

Efferalgan contains 412.4 mg of sodium 1 tablet, patients that should be taken into account, located on a strict low-salt diet. The tablets contain sorbitol, so the drug should not be used fructose intolerance, low absorption of glucose and galactose, isomaltase deficiency.

Effered tablets are slippery: overdose

Symptoms: pale skin, anorexia, nausea, vomiting; gepatonekroz (the severity of necrosis due to intoxication is directly dependent on the extent of overdose). Toxic effects in adults may, after receiving a dose of paracetamol 10-15 g: increase in liver transaminases, increased prothrombin time (through 12-48 h after administration); a full-blown liver disease manifests itself through 1-6 days. Rarely – fulminant hepatic failure, which may be complicated by renal failure (tubular necrosis).

Treatment: first 6 h after overdose – gastric lavage, introduction of donators SH-groups and precursors of glutathione synthesis – through methionine 8-9 hours after the overdose, and N through -atsetiltsisteina 12 no. The need for additional therapeutic interventions (further introduction of methionine, in / in a N -atsetiltsisteina) determined by the concentration of paracetamol in the blood, as well as the time, since his admission.

Effered tablets are slippery: drug interaction

Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes the possibility of severe intoxication with small overdoses of the drug.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxicity of paracetamol.

Paracetamol reduces the effectiveness of drugs urikozuricheskih.

While the use of paracetamol, ethanol contributes to the development of acute pancreatitis.

Effered tablets are slippery: terms of dispensing from pharmacies

The drug is resolved to application as an agent Valium holidays.

Effered tablets are slippery: terms and conditions of storage

The drug should be stored out of reach of children, dry place at temperatures no higher than 30 ° C. Shelf life – 3 year.