Didrogesteron

When ATH:
G03DB01

Pharmacological action.
Progestogens.

Application.

Progesterone deficiency, incl. infertility, abortion (habitual, threatening), endometriosis, dysmenorrhoea, Irregular menses, secondary amenorrhea, dysfunctional uterine bleeding; premenstrual syndrome; to neutralize the proliferative effect of estrogens on the endometrium during hormone replacement therapy in menopause.

Contraindications.

Hypersensitivity, syndrome, Dubin - Johnson, Rotor syndrome.

Restrictions apply.

If concomitant use of estrogen: impairment of renal function, cardiovascular diseases, diabetes, epilepsy, migraine.

Pregnancy and breast-feeding.

It can be applied during pregnancy. Provided with breast milk. Breastfeeding during maternal treatment is not recommended.

Side effects.

Metrorragija (breakthrough bleeding, stoped increasing doses).

Cooperation.

Inductors of microsomal liver enzymes, incl. phenobarbital, can speed up and reduce the effect of biotransformation.

Overdose.

Treatment: symptomatic, gastric lavage.

Dosing and Administration.

Inside, individually, depending on the nature and severity of the disease.

Infertility: by 10 mg / day from the 11th to 25th day of the cycle. Treatment is carried out continuously for 3-6 consecutive cycles or more: in the case of pregnancy it is recommended to continue treatment in the first months as suggested in habitual abortion. Threatened abortion: 40 mg dose, then 10 mg every 8 h until symptoms disappear. After the disappearance of the symptoms of treatment an effective dose is continued for 7 days, then gradually reduce the dose. If the symptoms reappear, then the treatment continued with the previous effective dose. Habitual abortion: 10 mg 2 twice a day to 20 weeks of gestation. Dysmenorrhoea: by 10 mg 2 twice daily from the 5th to 25th day of the cycle. Amenorrhea: in combination with estrogen (1 every day from the 1st to the 25th day of the cycle) - By 10 mg dydrogesterone 2 twice daily from the 11th to 25th day of the cycle. Irregular menstruation: by 10 mg 2 twice daily from the 11th to 25th day of the cycle. Endometriosis: by 10 mg 2-3 times daily from the 5th to 25th day of a cycle and / or continuously. Dysfunctional uterine bleeding: by 10 mg 2 times a day for 5-7 days in combination with estrogens (to stop) or 10 mg 2 twice daily from the 11th to 25th day of the cycle (for prophylaxis). In postmenopausal: by 10 mg / day for 14 days during the 28-day cycle (with continuous estrogen regimen) or the same dose during the last 12-14 days of estrogen (under cyclic pattern of estrogen therapy). When inadequate (biopsy or ultrasound) reactions to drug progestogen dose increased to 20 mg / day.

Cautions.

It should be taken into account, that hormone replacement therapy is not appointed without a general medical examination, including a pelvic examination. It is recommended that regular mammography. Abnormal bleeding and pathological changes, revealed during gynecological examination, can serve as an indication to the study of the endometrium.

Cooperation