Datura yndeyskyy – Inox data
An annual herbaceous plant 70-80 cm, families paslenovыh (Solanaceae). It grows everywhere in central Russia. For medical purposes use the leaves, which are harvested in July - August.
The chemical composition of Indian dope
The leaves of Indian dope contains tropane alkaloids - scopolamine, giosciamin, atropine, etc.. Besides, a plant found tannin, carotene, as well as essential oil, which publishes specific aroma of tobacco. The main plant alkaloid scopolamine hydrobromide salt is an ester scopine and tropic acid.
The pharmacological properties of Datura Indian
The pharmacological properties of Datura Indian determined mainly by the content in the plant scopolamine. Although the scopolamine similar in chemical structure to atropine, it has a number of distinctive features. Scopolamine has sedative, calming effect on the central nervous system, depresses motor activity and behavioral responses of animals. With increasing doses of hypnotic effect is observed skopolamtsna.
Acting on holinoreaktivnye structure of the higher parts of the CNS, Mr. Scopoli prevents transmission of nerve impulses to the motor neurons of the spinal cord. The result is a calming, sleeping pills and reduce locomotor activity action alkaloid. It marked its anticonvulsant effect, the ability to potentiate the sedative effect of narcotics and a depressing effect on respiratory function.
Like atropinu, Scopolamine has holinoliticheskimi and peripheral characteristics - gives the expressed, but short-term effect of mydriatic, relaxes smooth muscle tone, It reduces the secretion of digestive glands and sweat glands, It speeds up the rate of heart contractions.
The use of Datura Indian medicine
Indian Datura is used in combination with leaves of henbane and belladonna as protivoastmati- iCal cigarettes. Scopolamine and hyoscyamine are part of the preparation "Aeron", which is used for prevention and treatment of sea and air sickness, as well as for the prevention and relief of attacks of Meniere's disease. Sometimes it is used to reduce saliva- sweating and in some surgical procedures.
Scopolamine gidrobromid indicated for the treatment of Parkinson's disease and muscular hyperkinesis, in psychiatry used as a sedative for manic states. Apply scopolamine and to prepare for anesthesia with analgesics (morphine, promedol) in anesthesiology. In ophthalmology practice in some cases used for diagnostic purposes to improve pupil instead of atropine.
Contraindications scopolamine and "Aeron" the same, that the appointment of atropine. It should take into account individual sensitivity to drugs and avoid overdosing them in connection with the possibility of strong excitation, gallyutsinatsii, thirst, dryness and other side effects.
Formulations of drugs dope Indian, Dosing and Administration
Scopolamine gidrobromid (Scopolamine hydrobromide) - Crystalline white powder, easily soluble in water. Assign inside and under the skin. In eye practicing 0,25 % water solution.
Single doses: 0,00025-0.0005 G (0,250.5 mg) or 0.5-1 ml 0,05 % solution. Higher doses for adults inside and under the skin: single 0,0005 g, daily 0,0015 g.
Available in powder and in ampoules 1 ml 0,05 % solution. Store locked up in a well-sealed banks orange glass in the dry, protected from light.
Pills "Aeron" skololamina contain camphor-sour 0,0001 Mr. hyoscyamine and camphor-sour 0,0004 g. When air and sea sickness appointed interior: prophylactically 30-60 minutes before going 1-2 tablets at reception and in the future, if necessary, 6-12 hours more 1 tablet. Higher doses for adults: single 2 tablets, daily 4 tablets. For children 7-9 years, the highest single dose 1 tablet, daily, 2 tablets, 10-14 Years - 11 single / g tablets, daily - 3 tablets. Children up 7 Aeron years is not indicated. When menerovskom symptom appointed 1 Aeron tablet 2-3 times a day.
