DULKOLAKS (Suppozitorii)

Active material: Bisakodil
When ATH: A06AB02
CCF: Laxatives, stimulating peristalsis
ICD-10 codes (testimony): I84, K59.0, K59.0.0, K60, K62.8.1, K94, Z51.4
When CSF: 11.08.01
Manufacturer: BOEHRINGER INGELHEIM INTERNATIONAL GmbH (Germany)

Pharmaceutical form, composition and packaging

◊ Rectal Suppositories white or slightly yellowish, torpedo-shaped, and “narrowing” in the base, smooth or slightly oily surface.

Excipients: vitepsol W45.

6 PC. – strips of aluminum foil (1) – packs cardboard.

DESCRIPTION OF ACTIVE SUBSTANCES.

Pharmacological action

Laxative, diphenylmethane derivative. Increases of mucus secretion in the colon, It accelerates and enhances its peristalsis. The action is due to direct stimulation of nerve endings in the lining of the colon.

Pharmacokinetics

Bisacodyl is not absorbed from the gastrointestinal tract. It is a prodrug, in an alkaline medium is hydrolyzed to yield a compound, is irritating to the gastrointestinal mucosa.

Testimony

Constipation, due to hypotension and sluggish motility of the colon (in particular, elderly patients; constipation after surgery, delivery). Regulation stool hemorrhoids, proctitis, anal fissures. Preparing for surgery, instrumental and radiological studies.

Dosage regimen

Inside adults – by 5-15 mg, for children 8-14 years – by 10 mg, 2-8 years – by 5 mg. Reception frequency 1 just for the night or in the morning for 30 minutes before eating. Rectal adult – 10-20 mg; for children 8-14 years – by 10 mg, 2-7 years – by 5 mg.

Side effect

On the part of the digestive system: possible colicky pain in the intestines, diarrhea (It can lead to excessive loss of fluid and electrolytes and, Consequently, development of muscle weakness, seizures, hypotension).

Contraindications

Ileus, strangulated hernia, acute inflammatory diseases of the abdominal cavity, abdominal pain of unknown origin, peritonitis, bleeding from the gastrointestinal tract, uterine bleeding, cystitis, spastic constipation, acute proctitis, Acute Hemorrhoids.

Pregnancy and lactation

Bisacodyl used with caution during pregnancy and lactation (breast-feeding).

Cautions

To apply caution in patients with liver and kidneys.

Do not use for a long time.

Do not take simultaneously with milk and alkaline mineral water.

Drug Interactions

In an application may decrease the concentration of digoxin in the blood plasma.