Methyluracil

When ATH:
D06BX

Pharmacological action

Immunostimulant, dioksometiltetragidropirimidin. Promotes normalization of nucleic acid metabolism, accelerates cell regeneration wounds, It accelerates the growth and maturation of the granulation tissue and epithelialization (incl. bystroproliferiruyuschih cells in the gastrointestinal mucosa), It stimulates erythro- and leykopoez, cellular and humoral immunity factors. It has anabolic activity, inflammatory action. When applied topically has also PHOTOPROTECTIVE action.

Pharmacokinetics

The data is not provided.

Testimony

Orally: leukopenia (mild forms, incl. which arose as a result of cancer chemotherapy, at x-ray- and radiation therapy), neutropenic angina, septic angina, anemia, thrombocytopenia, intoxication benzolom, radiation sickness, convalescence (after severe infections), gastric ulcer and duodenal ulcer, vyalozazhivayuschie wounds, burns, fractures, hepatitis, pancreatitis.

For outdoor use: vyalozazhivayuschie wounds, burns, fractures, photodermatitis; sores, bedsores, deep wounds.

For topical application,: proctitis, sigmoidit, yazvennыy colitis.

Dosage regimen

Inside, during or after a meal, by 500 mg 4 times / day (if necessary – to 6 time / day); Children from 3 to 8 years – by 250 mg, senior 8 years – by 250-500 mg 3 times / day. The course at the diseases of the digestive tract – 30-40 days; in other cases it may be shorter.

When applied topically dosing regimen set individually, depending upon the dosage form. Frequency of dressing changes depends on the depth and area of ​​the wound surface, the intensity of the presence of exudation and necrotic masses.

Rectal use in adults 0.5-1 g 3-4 times / day; in children 3-8 years – by 250 mg / day, aged 8-15 years – by 500 mg / day. A course of treatment – from 1 Sun. to 4 Months.

Side effect

Maybe: allergic reactions; ingestion – headache, dizziness, heartburn.

Contraindications

Hypersensitivity to metiluratsilom.

Orally: leukemia (leukemic form, particularly myeloid), limfogranulematoz, hemoblastoses, malignant diseases of the bone marrow.

For external and local application: excessive granulation in the wound.

Cautions

Formulations methyluracil should be used strictly according to the respective indications.

Drug Interactions

The data is not provided.