Detralex: instructions for using the medicine, structure, Contraindications

Active material: Diosmin, Hesperidin
When ATH: C05CA53
CCF: Venous drug
ICD-10 codes (testimony): I84, I87.2
When CSF: 01.15.01.01
Manufacturer: Servier Laboratories (France)

Detralex: dosage form, composition and packaging

Pills, Film-coated orange-pink, Oval; of presentations – from pale yellow to yellow, inhomogeneous structure.

Excipients: gelatin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl, talc, Purified water.

The composition of the coating film: macrogol 6000, sodium lauryl, premix for film coating of orange-pink color (glycerol, magnesium stearate, gipromelloza, iron oxide yellow, iron oxide red, Titanium dioxide).

15 PC. – blisters (2) – packs cardboard.
15 PC. – blisters (4) – packs cardboard.

Detralex: pharmachologic effect

Preparation, used in violation of venous circulation. Detralex^® It has a venous and angioprotective properties. The drug reduces the extensibility of the veins and venous stasis, It reduces capillary permeability and increase their resistance. Clinical studies confirm the pharmacological activity of the drug in relation to indicators of venous hemodynamics.

A statistically significant dose-response effect was demonstrated in the following vein plethysmographic parameters: venous capacitance, venous distensibility, venous emptying time.

The optimum ratio of the dose and the effect is observed at the reception 2 tablets.

Improves venous tone: using venous occlusion plethysmography was shown to reduce the time of venous emptying. Patients with signs of pronounced microcirculatory disorders observed (statistically significant), compared to placebo, increase in capillary resistance, an estimated measured angiostereometricheski, after therapy detraleks^®.

Proven therapeutic efficacy in the treatment of functional and organic chronic venous insufficiency of the lower extremities, as well as in the treatment of hemorrhoids proctology.

Detralex: pharmacokinetics

Metabolism

The drug undergoes active metabolism, as evidenced by the presence of phenolic acids in urine.

Deduction

T_1/2 Diosmin is 11 no.

Diosmin is excreted mainly in the faeces. The kidneys remove 14% of the dose.

Detralex: testimony

Simptomaticheskaya intravenous therapy-limfaticheskoy nedostatochnosti:

• feeling of heaviness in the legs;
• pain;
• “Morning fatigue” Foot.

Cimptomaticheskaya treatment of acute hemorrhoids.

Detralex: dosing regimen

The drug is prescribed inside.

The recommended dose intravenous-limfaticheskoy nedostatochnosti – 2 tab. / day (1 tab. – in the middle of the day and 1 tab. – in the evening during meals).

The recommended dose acute hemorrhoids – 6 tab. / day (by 3 tab. morning and 3 tab. in the evening) during 4 days, then – by 4 tab. / day (by 2 tab. morning and 2 tab. in the evening) during subsequent 3 days.

Detralex: side effects

The frequency of adverse reactions is represented by the following gradation: Often (>1/10), often (>1/100, <1/10), moderately (>1/1000, <1/100), rarely (>1/10 000, <1/1000), rarely (<10 000), including isolated reports.

From the digestive system: often – diarrhea, nausea, vomiting, dyspepsia.

CNS: rarely – dizziness, headache, general malaise.

Dermatological reactions: rarely – rash, itch, hives.

Detralex: Contraindications

- Hypersensitivity to the drug.

Detralex: Pregnancy and lactation

So far, there were no reports of any side effects when using the drug in pregnant women.

Unknown, whether it is allocated diosmin with breast milk in humans, therefore not recommended during lactation.

IN experimental studies teratogenic effects detraleks^® not observed.

Detralex: Special instructions

During exacerbation of hemorrhoids use of this drug does not replace specific treatment other anal disorders. The duration of treatment should not exceed the recommended deadlines. In that case, If symptoms do not disappear after a short treatment, should undertake to revise the proctology examination and ongoing therapy.

In the presence of venous circulation disorders maximum effect of treatment is provided by a combination of a healthy, a well-balanced lifestyle, in which it is desirable to avoid long exposure to the sun, long stay on his feet, and reduce overweight, hiking and, in some cases, – wear special stockings, improves blood circulation.

Effects on ability to drive vehicles and management mechanisms

The drug does not affect the ability to drive and perform work, requiring a high rate of psychomotor reactions.

Detralex: overdose

Cases of drug overdose Detraleks^® not reported.

Detralex: drug interaction

Drug Interactions drug Detraleks^® not disclosed.

Detralex: terms of dispensing from pharmacies

The preparation is available on medical prescription.

Detralex: terms and conditions of storage

List B. The drug should be stored out of reach of children. Shelf life – 4 year. Do not use after expiration date, on the package.

Used sources

1. Detralex
2. Clinical efficacy of Detralex in treatment of women with pelvic varicose veins
3. Study of Antiinflammatory Effects of Detralex