Desloratadine

When ATH:
R06AX27

Characteristic.

White or almost white powder. Slightly soluble in water, very soluble in ethanol and propylene glycol. Molecular weight 310,8.

Pharmacological action.
Antihistamine, antiallergic, anti-inflammatory.

Application.

Symptomatic treatment of seasonal and perennial allergic rhinitis, chronic idiopathic urticaria.

Contraindications.

Hypersensitivity, pregnancy, lactation. Syrup (additionally, due to the presence in the composition of sucrose and sorbitol): hereditary fructose intolerance transmitted, malabsorption of glucose / galactose or failure of sucrose / isomalt.

Restrictions apply.

Severe renal insufficiency, childhood (to 1 year), childhood (to 12 years) for tablet forms (Safety and efficacy have not been determined).

Pregnancy and breast-feeding.

Contraindicated in pregnancy.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

At the time of treatment should stop breastfeeding (It passes into breast milk).

Side effects.

Pills. Increased fatigue (1,2%), dry mouth (0,8%), headache (0,6%). Very rarely - tachycardia, heartbeat, increase in liver enzymes, increasing the concentration of bilirubin, allergic reactions, including anaphylaxis, and rashes.

Syrup. Children under the age of 2 The following years were marked adverse events (frequency slightly higher, than with placebo): diarrhea, fever, insomnia.

Children 2-11 years, the frequency of adverse events was comparable to placebo.

In adults and adolescents over 12 years (frequency slightly higher, than with placebo): fatigue, dry mouth, headache.

When applied at the recommended dose of desloratadine 5 mg / day incidence of somnolence was not higher, than with placebo.

Among the very rare side effects observed dizziness, drowsiness, tachycardia, heartbeat, abdominal pain, nausea, vomiting, dyspepsia, diarrhea, elevated levels of bilirubin, liver enzymes in serum, allergic reactions (anaphylaxis, angioedema, itch, rash, hives).

Cooperation.

In the study of drug interactions with multiple joint application of desloratadine with ketoconazole, Erythromycin, Azithromycin, fluoxetine and cimetidine clinically significant changes in plasma concentrations of desloratadine is not revealed. Simultaneous food intake does not affect the distribution of body dezlotadina. Dezlotadin does not increase the effect of alcohol on the central nervous system.

Overdose.

Symptoms: increased severity of adverse reactions.

Treatment: gastric lavage, appointment of activated carbon, if necessary - symptomatic therapy. Hemodialysis nyeeffyektivyen. Efficiency of Peritoneal dialysis is not installed.

Dosing and Administration.

Inside, regardless of the meal, Adults and adolescents aged 12 years and older — 5 mg / day. Babies (Syrup) aged 1 Year to 5 years - 1,25 mg / day, 6-11 years - 2,5 mg / day.

Precautions.

It does not set the effect of desloratadine on ability to drive vehicles and management mechanisms.