Active material: deoxyribonucleat sodium
When ATH: L03A
CCF: Immunomodulator
ICD-10 codes (testimony): A15, A40, A41, A56.0, A56.1, B96.0, D25, i20, I73.0, I73.1, I73.9, I79.2, I83.2, J44, K12, K25, K26, K29, M05, N40, N41, N70, N71, N80, T30, Z51.8
When CSF: 14.01.09
Manufacturer: TEHNOMEDSERVIS ZAO FP {Russia}
The solution for the / m clear, colorless, without foreign impurities.
| 1 ml | 1 fl. | |
| deoxyribonucleat sodium | 15 mg | 30 mg |
Excipients: sodium chloride (0.9 g), water d / and (to 100 ml).
2 мл – флаконы стеклянные (10) – поддоны (1) – пачки картонные.
The solution for the / m clear, colorless, without foreign impurities.
| 1 ml | 1 fl. | |
| deoxyribonucleat sodium | 15 mg | 75 mg |
Excipients: sodium chloride (0.9 g), water d / and (to 100 ml).
5 мл – флаконы стеклянные (5) – поддоны (1) – пачки картонные.
Immunomodulator, affects cellular and humoral immunity. Immunomodulatory effect Derinat® caused by stimulation of B-lymphocytes, activation of T-helper cells. Derinat® It activates the body's non-specific resistance, optimizing the inflammatory reaction and immune response to the bacterial, viral and fungal antigens. Derinat® It stimulates reparative and regenerative processes.
Increases resistant to infection. Adjusts hematopoiesis (normalizing the number of leukocytes, lymphocytes, granulocytes, fagotsitov, Platelet). Having expressed lymphotropic, Derinat® It stimulates drainage detoxification function of the lymphatic system. Derinat® significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiotherapy.
Absorption and distribution
Rapidly absorbed from the injection site when the / m introduction and lymphatic spread to organs and tissues. Deoxyribonucleat sodium has a high affinity for bodies of hematopoiesis, It has been actively involved in cellular metabolism, embedding into cell structures. Maximally accumulated in the bone marrow, lymph nodes, Thymus, spleen, в меньшей степени – в печени, brain, stomach, small and large intestine.
In the phase of intensive preparation revenue into the blood redistribution between plasma and formed elements of blood, in parallel with the metabolism and excretion. After a single injection for all concentration-time curve, describing the change in drug concentration in the investigated organs and tissues, characterized by rapid phase increase and decrease the concentration of fast phase in the range of 5-24 no. After the / m of Cmax achieved through 5 no. The drug crosses the blood-brain barrier. Cmax drug in the brain is achieved by 30 m.
Metabolism and excretion
Deoxyribonucleat sodium is metabolized in the body. Write mainly kidneys and partially with faeces. T1/2 when i / m administration is 72.3 no.
- Radiation damage;
- A violation of hematopoiesis;
- Mielodeprescia and resistance to cytostatics in cancer patients, develop on the background of cytostatic and / or radiation therapy (stabilization of hematopoiesis, reduction of cardio- and myelotoxicity of chemotherapeutic agents);
- Stomatitis, induced by cytostatic therapy;
- Gastric ulcer and duodenal ulcer, erosive gastro;
- CHD;
- Obliterating vascular diseases of the lower extremities stage II-III;
- Sores, nonhealing wounds;
- Odontohennыy sepsis, pyo-septic complications;
- Rheumatoid arthritis;
- Burn disease;
- Preoperative and postoperative periods (in surgical practice);
- Chlamydia, ureaplazmoz, Mikoplasmosis;
- Endometritis, salpingo-oophoritis, endometriosis, fibroids;
- Prostatitis, benign prostatic hyperplasia;
- Chronic obstructive pulmonary disease;
- Pulmonary tuberculosis, inflammatory diseases of the respiratory tract.
Derinat® appointed adult / m (techenie1-2 in minutes) in an average single dose of 75 mg (5 ml solution for i / m administration 15 mg / ml) intervals administration 24-72 no.
At CHD appoint / m 5 ml 15 mg / mL in 48-72 no, курс лечения – 10 injection.
At gastric ulcer and duodenal ulcer appoint / m 5 ml 15 mg / mL in 48 no, курс лечения – 5 injection.
At oncological diseases – в/м 5 ml (75 mg / day) through 24-72 no, курс лечения – 10 injection.
IN Gynecology (endometritis, Chlamydia, ureaplazmoz, Mikoplasmosis, salpingo-oophoritis, fibroids, endometriosis) – в/м 5 ml 15 mg / mL in 24-48 no, курс лечения – 10 injection.
IN andrologii (prostatitis, benign prostatic hyperplasia) – в/м 5 ml 15 mg / mL in 24-48 no, курс лечения – 10 injection.
At tuberculosis – в/м 5 ml 15 mg / mL in 24-48 no, курс лечения – 10-15 injection.
At acute inflammatory diseases – в/м 5 ml 15 mg / mL in 24-72 no, курс лечения – 3-5 injection.
At chronic inflammatory diseases – в/м 5 ml 15 mg / ml: first 5 injections at intervals 24 h each, последующие – каждая с интервалом 72 no, общий курс лечения – 10 injection.
When using the solution 15 mg / ml 2 ml / m administered daily injections, Doing recalculated, until the course dose 375-750 mg.
In children multiplicity / m administration is the same, in adults. Children under 2 years drug administered in an average single dose 7.5 mg (0.5 ml solution for i / m administration 15 mg / ml), in children aged 2 to 10 years single dose is determined by calculating 0.5 ml per year of life. In childrenolder 10 years The average single dose is 75 mg (5 ml solution for i / m administration 15 mg / ml), курсовая доза – до 5 injections.
Maybe: in patients with diabetes is marked hypoglycemic effect, which should be taken into account, controlling the blood glucose level.
- Hypersensitivity to the drug.
The patient should be warned, that before the application of the drug during pregnancy and lactation is necessary to consult a doctor. The appointment of the drug during pregnancy should estimate the expected benefit to the mother and the potential risk to the fetus.
The drug has no embryotoxic, teratogenic and carcinogenic.
Perhaps s / c administration of the drug.
The drug potentiates the therapeutic effect of basic therapy for stomach ulcers and duodenal ulcers.
Derinat® reduce iatrogenic basic drugs for the treatment of rheumatoid arthritis with achievement 50% and 70% improvement on a number of integrated indicators of disease activity.
Surgical sepsis introduction Derinat® in the complex therapy causes a decrease in the level of intoxication, activation of immunity, normalization of hematopoiesis, improves the functioning of organs, responsible for detoxification processes of the internal environment (incl. lymph nodes, spleen).
According to recent clinical studies have proven the effectiveness of Derinat in patients with acute exacerbation of COPD of varying severity with standard therapy. Assign / m 5 ml 15 mg / mL in 24-48 no, курс лечения – 5-10 injection.
Overdose symptoms are not observed.
Application Derinat® in complex therapy improves the efficiency and reduce the duration of therapy, with a substantial reduction of doses of antibiotics and antiviral agents, with increasing periods of remission.
Derinat® It increases the effectiveness of antitumor antibiotics anthracyclines, cytostatics.
The drug is released under the prescription.
The drug should be stored out of reach of children, dry, dark place at a temperature of 4 ° to 20 ° C. Shelf life - 5 years.
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