Deferoxamine

When ATH:
V03AC01

Characteristic.

White powder. Soluble in water and slightly soluble in methanol.

Pharmacological action.
Complexing.

Application.

Acute and chronic toxicity iron, iron overload (incl. in blood transfusions).

Contraindications.

Hypersensitivity, anurija.

Restrictions apply.

Pregnancy, lactation.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Hypotension, collapse, dizziness, convulsions, dyspepsia, of the liver and kidneys, thrombocytopenia, allergic skin reactions. При применении в высоких дозах и/или длительно — нарушение периферического и сумеречного зрения, tsvetovospriyatiya, cataracts, hearing loss in the high frequency range.

Dosing and Administration.

/ M, n / a, I / (rarely). При хронической интоксикации вводят в/м — 0,5–1 г/сут или п/к — 20–40 мг/кг/сут, при острой — в начальной дозе 1 g, then (if necessary) - By 500 mg every 4 no, постепенно увеличивая интервалы между инъекциями до 12 no (daily dose should not exceed 6 g). In / in the introduction (at the same doses) permissible only when a serious condition of the patient, скорость инфузии не должна превышать 15 mg / kg / hr.

Precautions.

Be wary appoint patients with renal insufficiency. During treatment requires regular inspection ophthalmologist and otolaryngologist.

Cautions.

Not shown in primary hemochromatosis. It gives the urine a characteristic reddish color.