DAZOLIK

Active material: Ornidazol
When ATH: P01AB03
CCF: Antiprotozoal drug with antibacterial activity
ICD-10 codes (testimony): A06, A07.1, A59, Z29.8
When CSF: 07.01.01
Manufacturer: Sun Pharmaceutical Industries Ltd. (India)

Pharmaceutical form, composition and packaging

Pills, coated white or nearly white, round, lenticular, with Valium on one side.

Excipients: sodium starch glycolate (Type A), starch, colloidal silicon dioxide, magnesium stearate, sodium lauryl, polyvinylpyrrolidone K90 (povidone), Talcum cleared, microcrystalline cellulose.

The composition of the shell: эudrazhit E-100, Titanium dioxide, polyethylene glycol 6000, isopropyl alcohol, acetone, Purified water.

10 PC. – strips (1) – packs cardboard.

Pharmacological action

Antiprotozoal drug. The mechanism of action involves a violation of the structure of DNA sensitive microorganisms.

It is active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, as well as against some anaerobic bacteria (incl. Bacteroides spp., Clostridium spp., Fusobacterium spp. and anaerobic cocci).

Pharmacokinetics

Absorption and distribution

After taking the drug inside ornidazol well absorbed from the gastrointestinal tract. Bioavailability - 90%. FROM_max achieved through 1-2 no.

Binding to plasma proteins - at least 15%. It penetrates through the BBB.

Metabolism and excretion

T_1/2 – about 13 no. Displays in the form of metabolites kidneys (60-70%) and faeces (20-25%), about 5% – in unchanged form.

Testimony

- Trichomoniasis;

- Ameʙiaz, amebnaya dysentery, extra-intestinal amebiasis (incl. amebic liver abscess);

- Giardiasis;

- Prevention of infections, caused by anaerobic bacteria, in operations on the colon and Gynecology.

Dosage regimen

At trixomoniaze adult appoint 500 mg 2 times / day for 5 days. Babies dose set based 25 mg / kg body weight 1 times / day one.

At amoebic dysentery adult and Children weighing more than 35 kg by 1.5 g 1 time / day, from weighing more than 60 kg – 2 g / day. Babies weighing less than 35 kg daily dose is set based 40 mg / kg body weight. A course of treatment - 3 day.

At other forms of amebiasis adults and children over 12 years - By 500 mg, children aged 7 to 12 years - By 375 mg, in aged 1 to 6 years - By 250 mg, to 1 year - By 125 mg. Multiplicity of destination 2 times / day (in the morning and in the evening); duration of therapy - 5-10 days.

At giardiasis adults and children weighing more than 35 kg - By 1.5 g 1 time / day, Children weighing less than 35 kg - By 40 mg / kg / day. The duration of therapy is 1-2 day.

To infection prevention, caused by anaerobic bacteria, appoint 0.5-1 g preoperatively and 0.5 g 2 times / day after surgery for 3-5 days.

Side effect

From the central and peripheral nervous system: headache, dizziness, disturbances of consciousness, tremor, rigidity, dystaxia, convulsions, sensory or mixed peripheral neuropathy.

From the digestive system: nausea, vomiting, diarrhea.

Contraindications

- Organic diseases of the central nervous system;

- I trimester of pregnancy;

- Lactation;

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated for use in the I trimester of pregnancy and lactation (breast-feeding).

Cautions

In the treatment of trichomoniasis, be sure to treat sexual partners.

The consumption of alcohol during treatment with the drug is not indicated disulfiramopodobnyh reactions (ornidazol not inhibit atsetaldegidrogenazu).

Overdose

Symptoms: epileptiform convulsions, depression, neuritis of peripheral nerves.

Treatment: symptomatic therapy, if convulsions - diazepam.

Drug Interactions

In a joint application ornidazole proximity effect anticoagulants (coumarin derivatives), It prolongs the muscle relaxant effect of vecuronium bromide.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, protected from light and away from children at a temperature no higher than 25 ° C. Shelf life - 3 year.