Klomyfen

When ATH:
G03GB02

Characteristic.

White or white with a creamy white crystalline powder. It is soluble in water, moderately soluble in alcohol.

Pharmacological action.
Antiestrogens.

Application.

Anovulatory infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (disgonadotropnaya form, secondary, postkontraceptivnaâ), galactorrhea (against the backdrop of a pituitary tumor), polycystic ovaries (синдром Штейна — Левенталя), синдром Киари — Фроммеля, androgen deficiency, oligospermatism, for the diagnosis of pituitary gonadotrophic function.

Contraindications.

Hypersensitivity, severe liver and / or kidney failure, uterine bleeding of unknown etiology, ovarian cyst, tumor or failure of the pituitary gland, pregnancy (incl. She suspected).

Pregnancy and breast-feeding.

Contraindicated in pregnancy.

Category actions result in FDA - X. (Animal tests or clinical trials revealed a violation of the fetus and / or there is evidence of the risk of adverse effects on the human fetus, obtained in research or practice; risk, associated with the use of drugs in pregnancy, greater than the potential benefits.)

Side effects.

From the nervous system and sensory organs: headache, dizziness, depression, fatigue, anxiety, insomnia, slowing of mental and motor responses, blurred vision.

From the digestive tract: nausea, vomiting, gastralgia, flatulence, diarrhea.

With the genitourinary system: cystic enlargement of the ovaries, dysmenorrhoea, thamuria, polyuria, polycyesis.

Other: tides, weight gain, lower abdominal pain, in the chest, testicular (males), hyperthermia, reversible hair loss, allergic skin reactions.

Cooperation.

Compatible with drugs gonadotropins.

Overdose.

Symptoms: nausea, vomiting, tides, visual disturbances, abdominal pain.

Treatment: simptomaticheskaya therapy.

Dosing and Administration.

Inside. Для стимуляции овуляции назначают по 50 mg 1 once a day at bedtime, starting from 5th day of the menstrual cycle for 5 days (при отсутствии цикла — в любое время); If there is no effect (ovulation does not occur within 30 days), увеличивают дозу до 150 мг/сут или удлиняют курс до 10 days. Курсовая доза не должна превышать 1 g. The onset of ovulation is determined by the presence of a biphasic basal body temperature, cyclical increase in average production of LH, increase in serum progesterone during the luteal phase of the probable average or menstruation women with amenorrhea. If ovulation has occurred, a pregnancy has not occurred, the course must be repeated. If held after ovulation was no menstrual bleeding, It should take into account the possible pregnancy.

Мужчинам для лечения олигоспермии назначают по 50 мг 1–2 раза в сутки в течение 3–4 мес (systematic control spermiogram).

Precautions.

Before and during treatment must be continued monitoring gynecologist, should check ovarian function, to carry out a vaginal examination, observe the phenomenon of "pupil", etc.. With an increase in ovarian cystic transformation or treatment with clomiphene to suspend normalization size of the ovaries. Continue therapy with minimal doses or shorten the period of treatment. The treatment is recommended to monitor liver function. You can not assign an exemption from work parties, professional activities which require rapid physical and mental reactions.

Cooperation