Citicoline

When ATH:
N06BX06

Pharmacological action

Nootropics. Citicoline, As a precursor of the key components of the cell membrane ultrastructural (primarily phospholipids), has broad spectrum of activity: It helps to restore damaged cell membranes, It inhibits the action of phospholipases, preventing excessive formation of free radicals, and also prevents cell death, acting on the mechanisms of apoptosis.

In the acute phase of stroke reduces the amount of damaged tissue, improving cholinergic transmission.

With traumatic brain injury reduces the duration of post-traumatic coma and severity of neurological symptoms.

Citicoline improves the symptoms observed during hypoxia: memory impairment, emotional lability, bezыniciativnostь, difficulty in carrying out daily activities and self-care. It is effective in the treatment of cognitive, sensory and motor neurological degenerative disorders and vascular aetiology.

Pharmacokinetics

Because citicoline is a natural compound, which is contained in the body, classic pharmacokinetic study can not be performed due to the complexity of quantifying the exogenous and endogenous citicoline.

Testimony

Ischemic stroke (acute phase); Ischemic and hemorrhagic stroke (recovery period); traumatic brain injury (acute and recovery period); cognitive disorders in degenerative and vascular diseases of the brain.

Dosage regimen

If ingestion – by 200-300 mg 3

B / in stroke and traumatic brain injury in the acute period – by 1-2 g / depending on the severity of disease for 3-7 days, with subsequent transition to the / m introduction or ingestion.

/ M – 0.5-1 g /

Side effect

From the central and peripheral nervous system: insomnia, headache, dizziness, excitation, tremor, numbness in limbs paralyzed.

From the digestive system: nausea, decreased appetite, changes in liver enzymes.

Allergic reactions: rash, itchy skin, anaphylactic shock.

Other: fever; in some cases – transient hypotensive effect, stimulation of the parasympathetic nervous system.

Contraindications

Vagotonia (the predominance of parasympathetic part of the autonomic nervous system); childhood and adolescence up 18 years; Hypersensitivity to citicoline.

Pregnancy and lactation

When pregnancy is permitted only if, when the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

If necessary, use of citicoline during lactation should decide the issue of termination of breastfeeding, since the data on the allocation of citicoline in breast milk are absent.

Cautions

Do not use simultaneously with citicoline drugs, containing meclofenoxate.

Drug Interactions

Citicoline enhances the effects of L-dihydroxyphenylalanine.