Horiogonadotropin alpha
When ATH:
G03GA08
Pharmacological action
Rekombinantnыy horionicheskiy gonadotropin. It has the same amino acid sequence, how and hCG, urophanic. Associates transmembrane receptors N on the surface of cells and theca ovarian granulosa. Causes ootsitarnogo initiation of meiosis, rupture of the follicle (Ovulation), the formation of the corpus luteum. It stimulates the production of progesterone and estradiol by the corpus luteum.
Pharmacokinetics
After p / to the introduction of an absolute bioavailability of approximately 40%, T1/2 – about 30 no.
Testimony
It is used in a complex assisted reproductive technologies (incl. for in vitro fertilization) to induce final follicular maturation and luteinization after stimulation with gonadotrophins preparations.
When anovulatory infertility or oligoovulyatornom to induce ovulation and luteal late stimulate the growth of follicles.
Dosage regimen
Enter n / a. Single dose – 250 g. Multiplicity of administration depends on the indications and treatment regimens.
Side effect
CNS: possible headache, feeling tired; rarely – depression, irritability, anxiety.
From the digestive system: nausea, vomiting, stomach ache; rarely – diarrhea.
On the part of the reproductive system: possible ovarian hyperstimulation syndrome; rarely – ovarian hyperstimulation syndrome, severe, breast tenderness.
Contraindications
Tumors in the hypothalamus and pituitary, voluminous ovarian tumors or cysts, not associated with polycystic ovary; vaginal bleeding of unknown origin; ovarian cancer, uterus, Breast; ectopic pregnancy within 3 previous months; thromboembolism; Primary ovarian insufficiency; Congenital malformations of genital organs, incompatible with pregnancy; uterine fibroids, incompatible with pregnancy; postmenopause; hypersensitivity to alpha horiogonadotropinu.
Cautions
Before treatment is necessary to establish the cause of infertility, the patient and her partner and assess prospective risks if pregnancy occurs. Especially it is necessary to take into account the symptoms of hypothyroidism, adrenal insufficiency, hyperprolactinemia, the presence of tumors in the hypothalamic-pituitary region, apply specific therapies.
To reduce the risk of ovarian hyperstimulation syndrome is recommended careful monitoring of ovarian response with ultrasound and determination of estradiol in the blood before starting treatment and during.
In comparison with natural insemination during stimulation increases the risk of multiple pregnancy. In most cases, twins are born. When applying methods of assisted reproduction number corresponds to the number of babies born embryos, transferred into the uterus.
Introduction horiogonadotropina alpha may affect the immunological picture of the level of hCG in the blood and in the urine within 10 days and cause false positive reactions during pregnancy test.
Against the background of horiogonadotropina alpha might be a slight stimulation of the thyroid gland.
Drug Interactions
The data is not provided.
