Chloroquine

When ATH:
P01BA01

Characteristic.

White or white with a light kremovatym crystalline powder, bitter taste. Easily soluble in water, very little - in alcohol.

Pharmacological action.
Protivoprotozoynymi, antimalarial, immunosuppressive, anti-inflammatory, antiarrhythmic.

Application.

Individual prevention and treatment of all types of malaria, vnekišečnogo amebiaza, in a combination therapy for chronic and subacute forms of systemic lupus erythematosus, Scleroderma, revmatoidnom ARTHRO, fotodermatozah, porphyria cutanea tarda, arrythmia, paroxysmal atrial fibrillation.

Contraindications.

Hypersensitivity, of the liver and kidneys, expressed the defeat of the heart muscle (a dysrhythmia), blood disease, Nervous System, psoriasis, porfirinurija, diseases of the retina and cornea, pregnancy.

Restrictions apply.

Deficiency of glucose-6-fosfatdegidrogenazы, retinopathy, epilepsy, Saint Martin's evil.

Side effects.

Disorders of the gastrointestinal tract (decreased appetite, abdominal pain), headache, dizziness, sleep disorders. With long-term appointment - corneal opacity, blurred vision, graying of hair, dermatitis, photosensitivity. Rare - myocardial injury and muscle, decrease in blood pressure, psychosis, seizures, leukopenia, thrombocytopenia.

Cooperation.

Antacids violate absorption, cimetidine increases the plasma concentration. The combination with other antimalarial drugs can give an antagonistic effect. Incompatible with drugs gold, penicillamine, phenylbutazone, cytostatics, levamisole (neurotoxicity and increases the risk of skin reactions). In combination with glucocorticoids increases the risk of myopathy and cardiomyopathy, with MAO inhibitors - toxicity, with ethanol - hepatotoxicity, with cardiac glycosides - glycoside intoxication.

Overdose.

Symptoms: headache, disturbance of consciousness, vomiting, visual disturbances, convulsions and collapse. Death can occur within 2 h after administration of the respiratory depression.

Treatment: gastric lavage; Activated carbon (dose, in 5 times the estimated dose of chloroquine). Perhaps the use of emetics. Pyeritonyealinyi dialysis.

Dosing and Administration.

Inside, I / drop. For the prevention of malaria in the first week 2 times, then 1 times in the same day of the week - by 500 mg. For the treatment of malaria: 1-Day once - 1 g, then, After 6-8 hours, -still 500 mg, on 2 and 3 days - 750 mg daily 1 reception. If necessary, enter / drip. Amoebiasis - a 500 mg 3 twice a day for 7 days, then - on 250 mg 3 times a day even 7 days, further for 2-6 months - on 750 mg 2 times a week; by - rheumatoid arthritis 250 mg 2 twice a day for 7 days, then - on 250 mg daily for 12 Months. In systemic lupus erythematosus - 250-500 mg daily; photodermatosis - within a week of 250 mg daily, then weekly - by 500-750 mg. Children under 1 at 1 day — 50 mg; in 2 and 3 days - 25 mg. Children 1-6 years - 1 day 125 mg, in 2 and 3 days - 50 mg. Children 6-10 years - 1 day 250 mg, in 2 and 3 days - 125 mg. Children 10-15 years 1 day — 500 mg, in 2-3 days - 250 mg. When extra-intestinal amebiasis children prescribed a daily dose 6 mg / kg, after 2 weeks of treatment, reduce the dose 2 times.