Hellebore Lobel - Veratrum lobelianum Bernh.
Family Liliaceae – Liliaceae
Hellebore Lobel - description of plants
Perennial herb with a fleshy vertical or oblique, a length of 5-8 cm, rhizome, with lots of threadlike roots. Stem upright, height 100 (170) cm, branched in the upper portion, at the base of a closed leaf sheaths. Leaves alternate lower - broadly, gabled, Folded, smaller upper lanceolate, veined with dugonervnym. Inflorescence - large panicle with many flowers. The flowers are yellow-green, Petals (6) arranged in two circles elliptical shape, equal size. Fruit - mnogosemyannaya yaytsevidnaya, trójścienna box. Seeds flat, cruise. Flowers in June - August.
Spread. It grows in moist mountain meadows and around mountain streams and swampy areas. Distributed by the high mountains at a level between 1000 and 2000 m n. in. m. It is found in northern and central part, and in Southern Europe.
Raw materials. Rhizome with the roots of hellebore Lobel.
The content of active substances in the hellebore Lobel
Rhizome and roots contain alkaloids 0.5-1.5%, prevailing in the rhizome. Alkaloids - steroid type and contain hydroxyl groups, which may be free - aminoalkogoli (alkaminy), esterified - essential alkaloids, and related glycosides - glycoalkaloids. Alkaminami are: veratramin, yervin, rubijervin, term, A alkaminy, IN, Cider.; glikoalkaloidы - veratrozin, psevdoyervin; essential alkaloids - tsevadin, germerïn, germidin, A protoveratrin, In protoveratrin.
Get more 18 IZ alkaloids chemerytsы Lobel.
In the aerial part of the plant also contain the alkaloids: glikoalkaloidы - solanin, germinalin, desacetyl verolozid, Essential alkaloids - veralozinin, germinalin.
The antihypertensive effect is efernye and alkaloids. This action is even more pronounced, more hydroxyl groups in the molecule are esterified.
The main effect of drug hellebore Lobel
Gipotenzivnoe.
Experimental and clinical evidence of therapeutic action hellebore Lobel
When experimental and clinical studies established the extremely high activity of alkaloids gipotensivnaya hellebore. Studies have shown, that the amount of alkaloids, when administered intravenously anesthetized dogs and cats reduces blood pressure in dose 2-5 gammas / kg m. m., and in doses of 10-20 GAMMA / kg m. t. decreases by more than 50% blood pressure compared with its initial level. However hellebore alkaloids also possess cardiotonic effect.
Introduction into the duodenum alkaloid amount hellebore decerebrated or anesthetized cats, as well as oral administration in the form of a sum of pellets with the addition of saponin (to accelerate the absorption intraintestinal) unanesthetized dogs with experimentally induced hypertension, also has a strong, prolonged hypotensive effect. Even higher hypotensive activity are allocated Ivanov germerinovaya and proveratrinovaya alkaloid fraction of hellebore.
Newer studies have shown, that Ceveratrum-hellebore alkaloids have a direct positive inotropic and negative chronotropic effect on the myocardium - strengthening the systole simultaneously accompanied by a lengthening of diastole.
The mechanical effect tseveratrum alkaloids is accompanied by the extension of the promotional potential of myocardial cells. A possible cause of mechanical and electrophysiological effects tseveratrum alkaloids believe they cause a prolonged increase cell membrane permeability to sodium salts.
Results of histomorphological studies on the effects of some isolated white hellebore alkaloid fractions show a stimulating effect on the thyroid gland.
Germinatsetaty been tested in the treatment of myasthenia gravis (Myasthenia gravis), because of their effect on striated muscle. Called after a single stimulation of the contraction of muscles under their influence intensifies, but it increases the duration of not much.
The use of hellebore in folk medicine
Hellebore is known use in veterinary medicine in the form of alcohol solution as an antiparasitic agent. In folk medicine, infusion is used externally for hellebore roots of vinegar as a means to stimulate hair growth and dandruff; previously used ointment, soderzhaschye hellebore, against scab and lice.
Side effects hellebore
Hellebore and everything is prepared from it are highly toxic drugs. Currently used some pure hellebore alkaloids for the treatment of severe hypertensive disease. Conduct it can only in a clinical setting. External application of hellebore can also cause severe, even fatal, poisoning.
