Berocca Plus

Active material: Combined preparation
When ATH: A11AA03
CCF: Polivitaminы macro- and trace elements
ICD-10 codes (testimony): E50-E64, E53, E54, E60
When CSF: 17.03.04
Manufacturer: BAYER CONSUMER CARE AG (Switzerland)

Pharmaceutical form, composition and packaging

◊ Effervescent tablets Valium, from pale orange to pale orange, with splashes of darker and lighter color; dissolve in water, emitting bubbles, to produce a solution with the smell of Orange.

Excipients: Citric acid anhydrous, natriya carbonate, anhydrous sodium carbonate,, sodium chloride, acesulfame potassium, Aspartame, mannitol, polysorbate 60, betakaroten (E160a), dye red beet (E162), orange flavor.

10 PC. – aluminium cylinders (1) – packs cardboard.
10 PC. – polypropylene cylinders (1) – packs cardboard.
10 PC. – aluminium cylinders (2) – packs cardboard.
10 PC. – polypropylene cylinders (2) – packs cardboard.
15 PC. – aluminium cylinders (1) – packs cardboard.
15 PC. – polypropylene cylinders (1) – packs cardboard.
15 PC. – aluminium cylinders (2) – packs cardboard.
15 PC. – polypropylene cylinders (2) – packs cardboard.
15 PC. – aluminium cylinders (3) – packs cardboard.
15 PC. – polypropylene cylinders (3) – packs cardboard.

◊ Pills, coated from pale orange to greyish-Orange, oblong, lenticular.

Excipients: lactose monohydrate, povidone K90 (E1201), sodium croscarmellose (E468), mannitol (E421), talc (E553b), magnesium stearate (Agent: e572).

The composition of the shell: opadraj II Brown (dextrose (E1200), gipromelloza (E464), Titanium dioxide (E171), coconut oil fractionated, iron oxide yellow (E172), iron oxide red (E172), iron oxide black (E172)).

10 PC. – blisters (3) – packs cardboard.
10 PC. – blisters (6) – packs cardboard.
10 PC. – blisters (10) – packs cardboard.
20 PC. – blisters (3) – packs cardboard.
20 PC. – blisters (5) – packs cardboard.

Pharmacological action

Combined preparation, drugs which is due to its composition of complex of vitamins and microelements.

B vitamins are involved in many metabolic reactions, incl. the synthesis of neurotransmitters.

Vitamin C (vitamin C) is a biological antioxidant and plays an important role in the inactivation of free radicals, increases the absorption of iron in the small intestine, affects the metabolism of folic acid and function of leukocytes. Stimulates the formation of connective tissue, bone, normalizes capillary permeability.

Calcium is involved in many physiological processes, enzyme systems and neurotransmission in combination with magnesium and vitamin b₆.

Magnesium participates in various reactions, including protein synthesis, the metabolism of fatty acids, the oxidation of sugars.

Zinc catalyst activates more than 200 is a component of many enzymes and proteins, hormones, neuropeptides, hormonal receptors, as well as directly involved in the synthesis of coenzymes, derived vitamin b₆.

The vitamin content in the product Berocca^® Plus selected for use in therapeutic purposes. The drug is used for conditions, accompanied by deficits or increased need for vitamins: with increased physical activity, during the long nervous strain, and stress; when inadequate and unbalanced nutrition (restricting diet); elderly; chronic alcoholism, nicotine addiction (smokers), as well as in the application of oral contraceptives in women.

Water-soluble vitamins do not accumulate in the body, so, under conditions, accompanied by an increased need for vitamins and minerals, the number of vitamins, coming with food, may not be sufficient.

Pharmacokinetics

The farmakokinetike drug Berocca^® Plus not available.

Testimony

— deficit or State, accompanied by an increased need for vitamins group b, vitamin c and zinc.

Dosage regimen

The drug is taken orally.

Adults and children aged 15 and older appoint 1 tab. / day.

Do not exceed the recommended daily dose of the drug.

The recommended duration of treatment is 30 days. The need for a second course of treatment a doctor determines individually.

When taking the pill, the coated, high water; effervescent pill previously dissolved in a glass of water.

Side effect

From the digestive system: < 5% – Lightweight temporary gastrointestinal disorders.

Allergic reactions: <0.01% – hives, rash, laryngeal edema.

From the hematopoietic system: in patients with a deficit glukozo-6-fosfatdegidrogenaza Ascorbic acid can cause hemolytic anemia.

Contraindications

- Hypercalcemia;

- Gipermagniemiya;

- Urolithiasis disease (nephrolithiasis, urolithiasis);

— hemochromatosis;

— giperoksalurija;

- Renal dysfunction;

— the deficit glukozo-6-phosphate dehydrogenase;

- Children up to age 15 years;

- Hypersensitivity to the drug.

FROM caution the drug should be used in patients with atrophic gastritis, bowel disease, pancreas, intake of vitamin deficiency syndrome in₁₂ or congenital deficiency of internal factor Castle.

Pregnancy and lactation

When applying Berocca^® Plus the recommended dose of negative impact of the drug on the course of pregnancy or health of the child is not revealed. However, during pregnancy the drug should be taken strictly for medical reasons.

Vitamins and minerals, contained in the product Berocca^® Plus, excreted in breast milk. Data on the safety of the drug when used in lactation are not available.

Cautions

Vitamin c may interfere with, the results of the test for determining the glucose in the urine, despite, that it does not affect the level of glucose in the blood. Vitamin c intake should continue for a few days before conducting such tests.

During dose Berocca^® Plus the staining of urine in yellow, that has no clinical significance and due to the presence in the preparation of riboflavin.

Product Berocca^® Plus does not contain fat-soluble vitamins. IN 1 tab. the drug contains a maximum daily dose of vitamin b₆ (Pyridoxine), Therefore, you should not exceed the recommended dosage.

IN 1 tablet contains 12.5% recommended daily intakes of calcium and 33.3% recommended daily intakes of magnesium. However, for the treatment of deficiency of calcium and magnesium accept only medication Berocca^® Plus is insufficient.

IN 1 tablet contains 272 mg of sodium, so patients, observe a low salt diet, It is recommended to take the drug Berocca^® Plus, in the form of coated tablets.

IN 1 Tablet of the drug contains 276 mg mannitol, corresponding 0.028 HEH and energy values 0.66 kcal, so the drug can be taken with patients with diabetes.

Patients, taking other medicines, should consult with your doctor before you start taking the drug Berocca^® Plus.

Effects on ability to drive vehicles and management mechanisms

Berocca^® Plus does not affect the ability to drive vehicles and Office moving mechanisms.

Overdose

There have been no cases of overdose.

Symptoms: There gastrointestinal disorders, such as diarrhoea and discomfort in the stomach. Excessive intake of vitamin b₆ (more 20 tablets/day and for a few months) can lead to symptoms of neuropathy.

Treatment: the patient should stop taking the drug and consult your doctor. Displaying symptomatic therapy.

Drug Interactions

Vitamin B₆ (pyridoxine), in a dose exceeding 5 mg, may neutralize the effect of levodopa in patients with Parkinsonism. However, such antagonism is not observed in the application of levodopa in combination with decarboksilaza inhibitor (eg, Benserazide, kardbidopa).

Tiosemikarbazon and 5-fluorouracil neutralize vitamin b₁. Antacid drugs inhibit vitamin resorption₁.

Neomycin, aminosalicylic acid and blockers gistaminovykh n₁-receptors reduce removals of vitamin b₁₂.

Oral contraceptives can reduce serum vitamin b₁₂, folic acid, Pyridoxine, ascorbic acid.

Acetylsalicylic acid reduces the absorption of Ascorbic acid by approximately one third.

Some patients, daily receiving Deferoxamine and vitamin c in a dose 500 mg, can be transient left ventricular dysfunction.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C. Shelf life for tablets, coated – 3 year, for effervescent tablets – 2 year.