Benserazide: instructions for using the medicine, structure, Contraindications
When ATH: N04BA02
Benserazide: pharmachologic effect
An inhibitor of the peripheral dopa decarboxylase. In combination with levodopa, it helps to reduce the formation of dopamine in peripheral tissues and increase the amount of levodopa, entering the CNS. Do not cross the BBB.
Benserazide: pharmacokinetics
In patients with Parkinson's after ingestion benserazide it is rapidly absorbed from the gastrointestinal tract, the extent of absorption – 58%. It is metabolized primarily in the gut, action against levodopa (in the case of a combination of levodopa benserazide) It is also carried out mainly in the intestine; in other regions of the body is metabolized to form trigidroksibenzilgidrazina. Benserazide is rapidly excreted in the urine in the form of metabolites, mainly during the first 6 hours, 85% is displayed during 12 no. Benserazide does not penetrate the blood-brain barrier in rats.
Benserazide: testimony
In combination with levodopa: Parkinson's disease, Parkinson's syndrome (except parkinsonism, drug-induced, in particular neuroleptics).
Benserazide: dosing regimen
Individual. The daily dose of benserazide (in combination with levodopa in the ratio 1:4) It varies between 37.5 mg 250 mg.
Benserazide: side effects
CNS: rarely – spontaneous movement, sleep disorders, ažitaciâ, dizziness, depression.
Cardio-vascular system: rarely – orthostatic hypotension, Arrhythmia.
From the digestive system: rarely – nausea, vomiting, anorexia, epigastric pain, dysphagia, ulcerogenic action (in predisposed patients).
From the hematopoietic system: rarely – thrombocytopenia.
The above-mentioned side effects occur when using benserazide in combination with levodopa.
Benserazide: Contraindications
Expressions of the liver, kidney, cardiovascular and / or endocrine, severe psychosis, zakrыtougolynaya glaucoma, melanoma, pregnancy, lactation, childhood, Hypersensitivity to benserazide.
Benserazide: Pregnancy and lactation
Is contraindicated in pregnancy and lactation (breast-feeding).
Benserazide: Special instructions
It is used in combination with levodopa, thus reducing its dose and severity of side effects, especially nausea, vomiting, Arrhythmia. There may be a tendency to early onset of dyskinesia and mental disorders, associated with levodopa therapy.
Benserazide in combination with levodopa should not be used during treatment with MAO inhibitors (except MAO-B inhibitor).
Effects on ability to drive vehicles and management mechanisms
During the period of benserazide in combination with levodopa should avoid activities, which requires high concentration of attention and fast psychomotor reactions.
Benserazide: drug interaction
When used in combination with levodopa, along with a decrease in a number of side effects in the nervous system and the cardiovascular system, there may be a tendency to early development of dyskinesias and mental disorders, due to the action of levodopa.
