BANEOЦIN (Powder)

Active material: bacitracin, Neomycin
When ATH: D06AX
CCF: The drug with antibacterial action for outdoor use
ICD-10 codes (testimony): I83.2, L01, L02, L03.3, L22, L30.3, L73.2, L73.8, L73.9, T79.3, Z29.2
When CSF: 06.05.03
Manufacturer: Sandoz GmbH (Austria)

Pharmaceutical form, composition and packaging

◊ Ointment for external application zheltovataya, Homogeneous, with a faint characteristic odor.

Excipients: Nipple, white soft paraffin.

20 g – aluminum tuba (1) – packs cardboard.

◊ Powder for external use fine, white to yellowish.

Excipients: a powdered sterilized (corn starch, containing not more than 2% magnesium oxide).

10 g – Polyethylene cans (1) with dispenser – packs cardboard.

Pharmacological action

Combined antibacterial drug for external use. It contains two antibiotics, has a bactericidal effect, neomycin and bacitracin.

Bacitracin is a polypeptide antibiotic, which inhibits bacterial cell wall synthesis.

Neomycin yavlyaetsya antibiotikom-aminoglikozidom, which inhibits bacterial protein synthesis.

Bacitracin active against Gram-positive (Streptococcus spp. /incl. gyemolitichyeskii streptococci /, Staphylococcus spp.) and certain Gram-negative microorganisms. Resistance to bacitracin is rare. It has good tissue tolerance; inactivate biological products, blood and tissue components is not marked.

Neomycin active against Gram-positive and Gram-negative bacteria. By using the combination of the two antibiotics achieved wide range of drug action and synergy of action against a number of microorganisms, eg, staphylococci.

Pharmacokinetics

Active ingredients, usually, not absorbiruyutsya (even damaged skin), Nonetheless, present in the skin of their high concentrations of. When applying the product to large swathes of skin lesions should take into account the possibility of systemic absorption of the drug.

Testimony

Treatment of infectious and inflammatory diseases of the skin, caused by sensitive microorganisms:

Powder

- Bacterial infection of the skin limited distribution, incl. oozing contagious impetigo, infected trophic ulcers of the lower extremities, infected eczema, bacterial diaper dermatitis, secondary bacterial infection in diseases, вызванных Herpes simplex, Varicella zoster (incl. varicella);

- Prevention of umbilical infections in newborns;

- Prevention of infection after surgery (incl. dermatological) procedures: postoperatively (after excision of tissue, kauterizacii, episiotomy, treatment of fractures, weeping wounds and sutures).

Ointment

- patchy skin infections, in t.ch.furunkuly, carbuncles (after surgery), Staphylococcal sycosis, deep folliculitis, gnoynıy gïdradenït, paronixija;

- bacterial skin infections of limited distribution, incl. contagious impetigo, infected ulcers of the lower extremities, secondarily infected eczema, secondary infection in dermatosis, tax, ssadinax, burns, in cosmetic surgery and transplantation of skin (and in order to prevent and to impregnate bandages);

- prevention of infection after surgery (in a combination therapy in postoperative).

Dosage regimen

The drug is applied thinly to the affected areas: powder – 2-4 times / day, ointment – 2-3 times / day (to enhance the effectiveness of possible application of the ointment under the dressing).

Application of ointments turundy preferably in the topical treatment of infected wounds and cavities (incl. bacterial infections of the external auditory canal without perforation of the eardrum, wounds or surgical incisions, healing by secondary intention).

At burns more 20% body surface Powder should be applied no more 1 times / day, especially in the case of loss of kidney function (as possible absorption of the active ingredient).

For external use neomycin dose should not exceed 1 g / day (matches 200 grams or ointment) during 7 days. Repeated aware of the maximum dose – no more 100 g.

Side effect

Allergic reactions: long-term use - redness, xerosis, skin rash, itch. In general allergic reactions occur type contact eczema (in 50% cases related to the cross-allergy to other aminoglycosides) and rare.

Systemic effects: with extensive lesions of the skin should consider the possibility of absorption of the drug and the development of general relativity- and nephrotoxic effects and disorders of neuromuscular conduction.

When applied topically Baneotsin^® generally well tolerated.

Contraindications

- Expressed by the human kidney (due to heart failure or renal);

- Disease-cochle vestibular;

- Extensive skin lesions (the risk of ototoxic effect it systemic absorption);

- Diseases of the eye (for the application of powder);

- Hypersensitivity to bacitracin, neomitsinu k or other aminoglycosides.

Pregnancy and lactation

Use of the drug Baneotsin^® during pregnancy and lactation is possible only in case, if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Cautions

Avoid contact with the eyes.

When used in doses, significantly higher than the recommended, due to possible absorption should pay attention to symptoms, indicating nephrotoxicity- or ototoxic reaction.

Since the risk of toxic effects increases with a decrease in the liver and / or kidney, in patients with hepatic and / or renal failure should be carried out blood and urine tests, together with audiometric examination prior to and during therapy with Baneotsin^®.

When possible absorption (extensive violations integrity of the skin), you need to watch out for possible signs of the advent of neuromuscular blockade, especially in patients with acidosis, myasthenia gravis (myasthenia gravis) or other neuromuscular diseases.

With the development of neuromuscular blockade shown calcium supplements or neostigmine.

With prolonged use of the drug is necessary to monitor the possible excessive growth of resistant organisms. If necessary, appropriate treatment.

In case the drug in children, patients with impaired liver function and kidney function, as well as a large surface to be treated, long-term use and deep skin lesions should first consult a doctor.

With the development of allergic reactions and drug superinfection should be abolished.

Overdose

Currently, cases of drug overdose Baneotsin^® not reported.

Drug Interactions

If there is a systemic absorption, that while the appointment of cephalosporins and aminoglycoside antibiotics, increases the risk of nephrotoxic reactions.

In an application Baneotsina^® with ethacrynic acid or furosemide increases the risk of general relativity- and nephrotoxic reactions.

In the case of systemic absorption, while the application Baneotsina^® opioid analgesics, anesthetics and muscle relaxants increases the risk of neuromuscular blockade.

There were no cases of incompatibility of bacitracin and neomycin.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or below 25 ° C. The drug in powder form should be stored away from light and moisture. Shelf life – 3 year.