Azoksimera bromide

When ATH:
L03AX

Pharmacological action

Immunomodulatory, detoxifying. It increases the body's resistance to infections (local, generalized). Immunomodulation due to direct effects on phagocytic cells and natural killer cells, stimulation of antibody production. It restores immune responses in severe forms of immunodeficiency, incl. in secondary immunodeficiency, due to infections (tuberculosis and others.), malignant neoplasms, treatment with steroids or cytostatics, complications of surgery, injuries and burns.

With sublingual application activates lymphoid cells, located in the bronchi, nasal, Eustachian tube, thereby enhancing the sustainability of these bodies to infectious agents.

For oral application activates lymphoid cells, found in the intestine, namely the B-cells, producing secretory IgA.

The consequence of this is to increase the stability of the gastrointestinal tract and respiratory tract to infectious agents. Besides, oral application activates tissue macrophages, which contributes to more rapid elimination of the pathogen from the body in the presence of the source of infection.

In the combined therapy enhances the effectiveness of antibacterial and antiviral agents, bronchodilators and glucocorticoids. It allows you to reduce the dose of these drugs and reduce the time of treatment. It improves the stability of cell membranes to the cytotoxic effects, reduce the toxicity of drugs. It has a pronounced detoxifying activity (due to the nature of the polymer preparation). It does not have mitogenic activity polyclonal, antigenic and allergenic properties.

It has a high bioavailability (89%) when i / m administration, Cmax observed after 1 hours after rectal and through 40 minutes after the / m. T1/2 — 30 and 25 min and at a rectal / m administration (rapid phase), 36,2 h and at a rectal / m administration and 25,4 hours at / in a (slow phase). It is metabolized in the body and is excreted primarily by the kidneys.

Dosing and Administration

Lyophilisate for solution for injection and topical. / M, / drip, adults 6-12 mg / day one (daily, a day or 1-2 times per week), Children from 6 Months of 0.1-0.15 mg / kg in 48-72 hours. The course of treatment 5-7 injections.

Sublingual or intranasal, at 0.1-015 mg / kg / day once daily for 10 days.

Suppozitorii. Rectal, intravaginal. Dosing and dose chosen physician, depending on body weight, diagnosis, acuteness and severity of the process, the patient's age. Rectal, for the night, After bowel cleansing, by 6 or 12 mg (1 supp.) once daily for 3 days, then at intervals 48 no (a course of treatment - 10 supp.). Intravaginal, by 12 mg (1 supp.) daily for 3 days, and then every other day (a course of treatment - 10 supp.). If necessary, repeat the treatment after 3-4 months.

Pills. Orally, sublingually. Adult doses 12 or 24 mg, teenagers at a dose 12 mg daily 1, 2 or 3 once a day, depending on the diagnosis and the severity of the disease.

Contraindications

Hypersensitivity, pregnancy, lactation.

Restrictions apply

For injectable forms: acute renal failure, Children up to age 6 Months (clinical experience is limited). Pill: acute renal failure.

Pregnancy and lactation

Contraindicated in pregnancy (there is no clinical experience with). At the time of treatment should stop breastfeeding.

Side effects

For injectable forms: soreness at the site of the / m.

Drug Interactions

The combination with antibiotics, antiviral, antifungal and antihistamines, bronholitikami, kortikosteroidami, cytostatics, beta-agonists.