Avertide - instructions for use of the drug, structure, Contraindications

The mechanism of action of the drug Avertid is to act on H1- и H3- histamine receptors in the labyrinth, vestibular nuclei of the CNS (central nervous system). Shows a pronounced H1-antagonistic effect on the receptors of the vessels of the inner ear, which contributes to local vasodilation and improvement of blood supply in the stria vascularis.

Indications and dosage:

Meniere's disease or syndrome; symptomatic therapy of vestibular vertigo.

Take by mouth. The dose and duration of the course is determined by the doctor individually.. Adults are prescribed 2-3 times / day during or after meals. The dosage of the drug Avertide is made with a syringe (included). Can be taken undiluted, drinking it with enough water, or dilute in water. The course of treatment is 2 weeks before 3 months. Adults are prescribed 8 mg (1 ml) three times/day. If necessary, increase the dose to 16 mg (2 ml) three times/day (or 24 mg (3 ml) twice/day). The maximum dose per day is 48 mg.

Overdose:

No data.

Side effects:

Headache, digestive disorders (vomiting, nausea, abdominal pain, flatulence), hypersensitivity reactions (angioedema, itch, rash, hives, anaphylaxis).

Contraindications:

Hypersensitivity to the constituent components of the drug Avertid, pheochromocytoma, use of disulfiram derivatives, under eighteen years of age, pregnancy (use only when prescribed by a doctor), lactation (for the period of treatment should stop breastfeeding). drug and alcohol: It is not recommended to drink alcohol during treatment with Avertid.

Interaction with other drugs and alcohol:

No data.

Composition and properties:

Structure:

Betagistin.

Product form:

Solution for oral administration (8 mg / ml) vial 60 ml

Pharmacological action:

The mechanism of action of the drug Avertid is to act on H1- и H3- histamine receptors in the labyrinth, vestibular nuclei of the CNS (central nervous system). Shows a pronounced H1-antagonistic effect on the receptors of the vessels of the inner ear, which contributes to local vasodilation and improvement of blood supply in the stria vascularis. H3-antagonistic effect of betahistine on the receptors of nerve cells of the vestibular nuclei leads to an improvement in microcirculation, increased release of histamine, increased capillary permeability, increase in fluid exchange in the microvasculature of stria vascularis, normalizing endolymph pressure in the cochlea and labyrinth. Besides, improves neuronal transmission by increasing the concentration of serotonin in the synapses. Inhibits the enzyme diamine oxidase, which inactivates histamine. Does not affect H2-histamine receptors of the stomach (does not increase the secretion of hydrochloric acid), has no sedative effect. Betahistine does not provoke extrapyramidal disorders and can be used in patients with Parkinson's syndrome..

Storage conditions:

general information

  • Sales form: over-the-counter
  • Current in-about: Betagistin

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