Avamys - instructions for use of the drug, structure, Contraindications

Avamis – nasal spray of therapeutic action against allergic rhinitis. Contains a fluorinated corticosteroid. The main component of the drug is fluticasone furoate, which has a pronounced anti-inflammatory effect.

Avamis: indications and dosage

The drug is used as a symptomatic therapy in patients, allergic rhinitis.

Nasal allergy - inflammation of the nasal mucosa, accompanied by breathing, abundant mucous secretions and sneezing. At the heart of the pathological process of allergic reaction.

Cause of allergic rhinitis (like any other types of allergic reactions) is a violation of the immune system, which excessively reacts to microscopic particles inhaled. Excessive response of the immune system and causes a typical symptoms.

Adults and adolescents over the age of 12 years are usually assigned according to 2 doses of the drug in each nasal passage 1 once a day. After achieving the desired therapeutic effect, the dose is reduced to 1 injection into each nasal passage 1 once a day.

The maximum daily dose of the drug is 110mcg, maintenance daily dose - 55 mcg. Children aged 6 to 12 years are usually assigned according to 1 dose of the drug in each nasal passage 1 once a day. If necessary, the dose can be increased to 2 injections into each nasal passage 1 once a day, and after achieving the desired therapeutic effect, they will return to the initial dose.

Avamis: rules for using Avamys nasal spray

Vial design

The nasal metered spray consists of a glass vial, placed in a plastic case with a protective cap, covering the spray tip (special device at the upper end of the spray). There are small holes in the bottom of the case., through which you can see the presence of the drug in a glass vial. On one side of the plastic housing is a large dosing button, when pressed, the drug is released through the nebulizer.

Preparation for use

Preparation is needed when using Avamys spray for the first time, and also if the vial was left open for a long time. This is necessary for injecting a standard dose of the drug. Preparation includes the following rules:

• Without removing the cap, shake the medicine bottle well. (no less 10 seconds).
• Remove the cap by pulling on it with your thumb and forefinger. (rice. E)
• The bottle must be brought to a vertical position and direct the tip away from you
• Then you need to press the button on the side several times (rice. IN), until the spray starts to come out of the tip in the form of a cloud
• After all the manipulations, the medicine is ready for use.

Application of Avamys nasal spray

1. Shake the medicine bottle thoroughly.
2. Remove the cap.
3. Clear your nose first.
4. Tilt your head forward and insert the tip into your nostril. In this case, the bottle must remain in an upright position. (rice. G).
5. The tip, when used, should be directed to the outer wall of the nose., not on the nasal septum. Thus, the medicine will get deeper into the nasal cavity..
6. While injecting the Avamys spray, simultaneously inhale through your nose (rice. N).
7. If the substance gets into the eyes, need to be rinsed with plenty of water.
8. After injection, remove the tip from the nostril and inhale through the mouth.
9. The dose of the drug can be increased to 2 once in each nostril, at the appointment of a doctor. Then steps 4-6 must be repeated in the same sequence.
10. The procedure for the second nostril is carried out in the same way., as described above.
11. Close the cap carefully after use.

Caring for a bottle of Avamys nasal spray

After each use, it is necessary to clean the tip of the vial to preserve its functions., as well as removing excess contaminants:

• Wipe the tip and the inside of the cap dry, pure matter (rice I and J). It is absolutely impossible to wash the tip with water!
• The use of sharp tools to clean the tip is also unacceptable..
• Close the bottle carefully after cleaning..

If the vial of Avamys does not work

• First of all, check the level of the remaining drug in the viewing window at the bottom of the vial.. If there is a small amount of substance left, the sprayer may not work..
• Inspect the vial for mechanical damage.
• Inspect the tip and its orifice for obstructions. Clean the tip as described above (No sharp objects!).
• With prolonged non-use of the drug Avamys, perhaps the atomizer does not work due to a thickened suspension. In this case, it is necessary to repeat the procedure for preparing the spray for use..

Important facts about Avamys nasal preparation

1. Avamys nasal spray is produced in bottles with orange glass. For, to verify the remaining amount of the drug in the vial, you need to look through a special window at the bottom of the bottle in the light.
2. The composition of the drug resembles a dense suspension. Therefore, without first shaking the package, spraying will not be possible..
3. For injection, the package design has a special button on the side. (rice. FROM)
4. If you find it difficult to press the button for the first time, or the button is too tight, use the fingers of both hands (rice. D).
5. After use, do not forget to close the bottle with a cap. The lid keeps the substance from contamination and seals the substance. Also, when the cap is closed, the button is blocked from accidental pressing..
6. It is impossible to clean the tip opening from the introduced contaminants with the help of sharp objects, otherwise the bottle of Avamys with liquid may be damaged.

Avamis: overdose

Currently reported drug overdose were reported. When using excessive doses of the drug, the patient's condition should be monitored. No specific antidote. In case of overdose, symptomatic therapy is indicated..

Avamis: side effects

When using the drug Avamys, various side effects were noted in patients..

From the respiratory system:

• nose bleed,
• ulcerative lesions of the nasal mucosa.

Allergic reactions:

• itching,
• rash,
• hives,
• anaphylactic shock (severe allergic reaction of immediate type, characterized by dramatically increased sensitivity of the organism to the reintroduction of allergen. Anaphylactic shock is one of the most severe complications of drug allergy.),
• angioedema (dangerous complication of an allergic reaction, in which the neck swells strongly and the structure in the upper respiratory tract is compressed).

Nervous system: headache.

organs of vision: transient visual impairment (transient blindness or decreased vision in one (two) eye).

With prolonged use of the drug in children, growth retardation may develop..

According to a clinical study on the assessment of the growth of adolescent children, receiving 110 mcg fluticasone furoate once daily, наблюдалась разница в скорости роста – 0,27 cm per year compared to the group, placebo.

Avamis: Contraindications

Individual hypersensitivity to the drug. The drug is contraindicated in patients, treated with ritonavir. The drug is not used to treat children under the age of 6 years. The drug should be used with caution in patients, suffering from severe liver dysfunction.

Avamis: use during pregnancy or lactation

There is very little information on the use of the drug during pregnancy and lactation.. During pregnancy and lactation, the active substance fluticasone furoate can only be used as a last resort., if the attending physician considers, that the therapeutic effect of the drug is greater for the mother, than the likelihood of a threat to the child.

With intranasal use of fluticasone furoate at the maximum recommended doses (110 g / day) reaches its concentration, which is generally not measurable, and therefore the potential for reproductive toxicity is expected to be very low. The penetration of fluticase furoate into human breast milk has not been studied.. Human fertility data not available.

Avamis: interactions with other drugs and alcohol

• With the combined use of the drug with corticosteroids for systemic use, possible systemic effects of Avamys should be taken into account.
• The combined use of the drug with ritonavir is contraindicated due to an increased risk of systemic effects of fluticasone furoate..
• With the simultaneous use of the drug with inhibitors of CYP 3A4, it is possible to increase the systemic effect of the drug Avamys, therefore, this combination should be used with caution..

Avamis: composition and properties

Structure:1 dose of Avamys contains: fluticasone furoate - 27.5 mcg.

Excipients: benzalkonium chloride solution.

Avamis: release form

Spray nasal for 30 or 120 doses in dark glass vials, by 1 vial with nasal adapter and cap in carton box.

Avamis: pharmachologic effect

Avamis - medicated nasal spray, which contains fluorinated corticosteroids.

The main active ingredient of the drug is fluticasone furoate., with strong anti-inflammatory properties. With intranasal use of a single dose, the systemic bioavailability of the drug is about 0,5%. When using the drug at a dose of 110 mcg 1 once a day, the plasma concentration of the drug is negligible and cannot be measured. The drug binds to plasma proteins within 99%. Breaks down when it enters the liver with the help of the CYP3A4 cytochrome P450 enzyme to form inactive degradation products. Excreted most often through feces.

Avamis: storage conditions

The drug is recommended to be stored in a dry place away from direct sunlight at a temperature of 15 to 25 degrees Celsius. Shelf life - 3 year. After the first use of the drug, the shelf life is 2 of the month.

Avamis: general information

Sales form: over-the-counter

• Current in-about: Fluticasone furoate
• Manufacturer: GlaxoSmithKlein Export, Great Britain
• Farm. Group: Medicines for the treatment of rhinitis