ASKORUTIKAL′ FORTE

Active material: Vitamin C, Calcium carbonate, Rutozid
When ATH: A11GB01
CCF: Complex vitamins with microelements
ICD-10 codes (testimony): E54, I83, I87.2, J06.9, J10, J30.1, L50
When CSF: 17.02.04
Manufacturer: PHARMACEUTICAL WORKS JELFA S.A. (Poland)

Pharmaceutical form, composition and packaging

◊ Pills, coated yellow-beige, longitudinal.

Excipients: carmellose sodium, microcrystalline cellulose, magnesium stearate.

The composition of the shell: gipromelloza, povidone, macrogol, Talcum cleared, Titanium dioxide, antifoaming emulsion, dye – iron oxide yellow.

10 PC. – blisters (2) – packs cardboard.

Pharmacological action

Combined preparation, pharmacological effect of which is due to its constituent components.

Vitamin C – It is not formed in the human body, and comes only with food. It has a metabolic effect. Antiplatelet and possesses strong antioxidant properties. Involved in the formation of tetrahydrofolic acid and the synthesis of steroid hormones, Collagen, procollagen. Regulates immunological reactions (activates antibody synthesis, C3 component compliment, interferon), promotes phagocytosis, It increases the body's resistance to infections. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, reduces vascular permeability, It reduces the need for vitamins B₁, B₂, A, E, Folic acid, pantothenic acid. Inhibits the release of histamine and accelerates degradation, inhibits the formation of prostaglandins and other mediators of inflammation and allergic reactions.

Rutozid – angioprotectornoe tool, a derivative of flavonoids, exhibits antioxidant and chelating action. It neutralizes uncontrolled reactions of free radicals and peroxides of the fatty acids, which lead to atherosclerotic changes and disrupt the function of the cell membranes. Rutoside causes inhibition of aldose reductase activity, reduces the concentration of fibrinogen in the blood, increases the elasticity of red blood cells, It inhibits the aggregation of blood platelets and reduces its viscosity, improving blood rheological parameters, especially in the microvasculature. Reduces the permeability of blood vessels, especially capillaries. Increases tone venous vascular wall. Anti-inflammatory and anti-allergic effect. Promotes Escrow ascorbic acid in tissues. Action rutoside enhanced ascorbic acid.

Calcium It is one of the most important macronutrient. It is a major component of bone, It plays an important role in maintaining the electrolyte balance of the body and the normal functioning of many regulatory mechanisms. It causes the normal blood clotting, normal nerve conduction and contractility of striated muscle. It influences the activity of many enzymes, and also performs the role of mediator, whereby chemical, physical or hormonal impulses are transformed into a specific biological effect.

Calcium reduces the permeability of blood vessel walls, Consequently, anti-inflammatory, decongestant, and anti-allergic effect protivoekssudativnoe, and also stimulates the protective functions of the body.

Pharmacokinetics

Data on the pharmacokinetics of the drug Askorutikal Forte is not provided.

Testimony

- prevention and treatment of hypo- beriberi and P and;

- complex therapy and prevention of infectious diseases (incl. SARS and influenza);

- the treatment of diseases, associated with impaired vascular permeability: phlebeurysm, edema of the lower extremities, due to chronic venous insufficiency; allergic diseases (hay fever, hives, photosensitivity).

Dosage regimen

The drug is taken orally.

Adults prophylactically: by 1 tab. 2 times / day, for therapeutic purposes: by 2 tab. 2 times / day.

Pregnancy and lactation the maximum daily dose – 2 tab.

Children over 5 years prophylactic and therapeutic purposes: by 1 tab. 1 time / day.

Duration of treatment – 3-4 of the week, depending on the nature of the disease and the effectiveness of treatment

Side effect

From the digestive system: very rarely - nausea, epigastric discomfort.

Other: rarely – allergic reactions, headache.

Contraindications

- Hypercalcemia (incl. in patients with hyperparathyroidism, hypervitaminosis D, multiple myeloma or bone metastases);

- Severe renal insufficiency;

- Children up to age 5 years;

- simultaneous use of sulfonamides and aminoglycosides;

- Hypersensitivity to the drug.

Carefully apply in states, accompanied by blood hypercoagulability and a tendency to thrombosis, in acute thrombophlebitis; due to the calcium content – in renal failure, Sarcoidosis, urolithiasis, diseases of the cardiovascular system; patients, receiving cardiac glycosides.

Pregnancy and lactation

Caution is advised to use the drug during pregnancy and lactation. The need for the appointment of the drug during pregnancy and lactation doctor determines individually.

Cautions

Patients with urolithiasis during treatment should drink plenty of fluids.

Ascorbic acid in high doses may cause false positive test result for the presence of glucose in urine, as well as false-negative test results for the presence of occult blood in the stool.

Effects on ability to drive vehicles and management mechanisms

The drug does not affect the ability to drive vehicles and working with moving machinery.

Overdose

Symptoms: high doses of calcium, It is taken by mouth to patients with renal insufficiency, may lead to hypercalcemia, symptoms are loss of appetite, gastrointestinal disorders, muscular weakness, polyuria, urolithiasis disease. Ascorbic acid in high doses can cause excessive removal of oxalic acid in urine, crystallization of urate, tsitratov, diarrhea.

Treatment: removal of the drug, symptomatic therapy under medical supervision.

Drug Interactions

Calcium salts, ingestible, reduce the absorption of tetracyclines and fluorine compounds (should be an interval 3 hours between the intake of drugs and calcium salts of data).

Vitamin D and parathyroid hormone increases the absorption of calcium, while calcitonin, Corticosteroids reduce calcium absorption. High doses of calcium, given simultaneously with cardiac glycosides (derivatives of digoxin and ouabain) potentiate their action and can cause cardiac arrhythmia.

Thiazide diuretics increases the reabsorption of calcium and create a risk of hypercalcaemia. The high dose of calcium in combination with vitamin D could attenuate the action of verapamil and other drugs, blocking calcium channels.

Ascorbic acid enhances the absorption of drugs of the penicillin,gland; reduces the clinical effect of heparin anticoagulants and. In more doses 1 g / day may reduce the effectiveness of tricyclic antidepressants, phenothiazine derivatives, and can also cause an increase in serum estrogen simultaneously applied.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, protected from light, at a temperature no higher than 25 ° C. Shelf life – 3 year.