ARBIDOL (Capsules)

Active material: метилфенилтиометил-диметиламинометил-гидроксиброминдол carboxylic acid ethyl ester
When ATH: L03AX
CCF: The antiviral and immunomodulatory drugs. Inducer of interferon synthesis
Codes ICD-10 (testimony): A08, A60, B00, B02, J06.9, J10, J15, J42, Z29.8
When CSF: 09.01.05.02
Manufacturer: OAO Pharmstandard-Leksredstva (Russia)

Pharmaceutical form, composition and packaging

◊ Capsules yellow color, size №3; contents of capsules – mixture, containing granules and powder from white to white with a greenish-yellowish or Valium a color shade.

Excipients: potato starch, microcrystalline cellulose, colloidal silicon dioxide (aэrosyl), krospovydon (Kollidon 25), calcium stearate.

Structure hard gelatin capsules: Titanium dioxide (E171), quinoline yellow (E104), colorant sunset yellow, metilgidroksiʙenzoat, propyl, acetic acid, gelatin or titanium dioxide (E171), quinoline yellow (E104), Yellow sunset (E110), gelatin.

5 PC. – packings Valium planimetric (1) – packs cardboard.
5 PC. – packings Valium planimetric (2) – packs cardboard.
5 PC. – packings Valium planimetric (4) – packs cardboard.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (4) – packs cardboard.

◊ Capsules with a white body and yellow cap, size №1; contents of capsules – mixture, containing granules and powder from white to white with a greenish-yellowish or Valium a color shade.

Excipients: potato starch, microcrystalline cellulose, colloidal silicon dioxide (aэrosyl), krospovydon (Kollidon 25), calcium stearate.

Composition of hard gelatin capsules: Titanium dioxide (E171), quinoline yellow (E104), colorant sunset yellow, metilgidroksiʙenzoat, propyl, acetic acid, gelatin or titanium dioxide (E171), quinoline yellow (E104), Yellow sunset (E110), gelatin.

5 PC. – packings Valium planimetric (1) – packs cardboard.
5 PC. – packings Valium planimetric (2) – packs cardboard.
5 PC. – packings Valium planimetric (4) – packs cardboard.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (4) – packs cardboard.

Pharmacological action

Viricide, It has immunomodulatory effects and protivogrippoznoe, specifically inhibits influenza A and B, Severe Acute Respiratory Syndrome (SARS). It prevents contact and penetration of viruses into the cell, suppressing the merger lipid envelope virus with cell membranes. It has interferon-inducing action, stimulating humoral and cellular immune responses, phagocytic function of macrophages, It increases the body's resistance to viral infections. Reduces the incidence of complications, associated with viral infection, as well as exacerbation of chronic bacterial diseases.

Therapeutic efficacy in viral infections manifested in reducing the severity of intoxication and clinical events, shortening the duration of illness.

It applies to low-toxic drugs (LD50 >4 g / kg). It does not have any negative effects on the human body when taken orally at recommended doses.

Pharmacokinetics

Absorption and distribution

After ingestion is rapidly absorbed from the gastrointestinal tract. FROM_max upon receipt of dose 50 mg achieved through 1.2 no, FROM_max upon receipt of dose 100 mg - 1.5 no.

The active ingredient of the drug Arbidol^® rapidly distributed to organs and tissues of the body.

Metabolism and excretion

It is metabolized in the liver. T_1/2 is 17-21 no.

About 40% excreted unchanged, mainly in the bile (38.9%) and a minor amount – kidney (0.12%). During the first day displayed 90% the dose.

Testimony

Prevention and treatment of adults and children:

- Influenza A and B, SARS, SARS, incl. complicated by bronchitis and pneumonia;

- Secondary immunodeficiency states;

- Chronic bronchitis, pneumonia and recurrent herpes infection (in the complex therapy).

Prevention of postoperative infectious complications and the normalization of the immune status.

In the combined therapy of acute intestinal infection rotavirus etiology in children older 3 years.

Dosage regimen

The drug is prescribed inside, before meals. A single dose adults and children over 12 years – 200 mg (2 caps. by 100 mg or 4 caps. by 50 mg), to children aged 6 to 12 years – 100 mg, from 3 to 6 years – 50 mg.

For non-specific prevention

At direct contact with patients with influenza and other acute respiratory viral infections adults and children over 12 years Arʙidol^® administered at a dose of 200 mg / day; children aged 6 to 12 years – 100 mg / day; children aged 3 to 6 years – 50 mg / day. The drug is taken 1 time / day. Course - 10-14 days.

IN during the epidemic of influenza and other acute respiratory viral infections, for the prevention of exacerbations of chronic bronchitis and recurrent herpes infection adults and children over 12 years drug administered in a single dose 200 mg; children aged 6 to 12 years – 100 mg; children aged 3 to 6 years – 50 mg. The drug is taken 2 once a week for 3 weeks.

To SARS prevention (in contact with the patient) adults and children over 12 years appoint 200 mg 1 times / day for 12-14 days; children aged 6 to 12 years – by 100 mg 1 time / day (before meals) during 12-14 days.

To prevention of postoperative infectious complications the drug is prescribed for two days before surgery, Then in the second and fifth days after surgery at doses: adults and children over 12 years – 200 mg, children aged 6 to 12 years – 100 mg, from 3 to 6 years – 50 mg.

For the treatment of

At influenza and other acute respiratory viral infections without complications adults and children over 12 years the drug is prescribed for 200 mg 4 times / day (every 6 no), children aged 6 to 12 years - By 100 mg 4 times / day (every 6 no), from 3 to 6 years - By 50 mg 4 times / day (every 6 no). A course of treatment – 5 days.

At influenza and other acute respiratory viral infections with the development of complications (incl. bronchitis, pneumonia) adults and children over 12 years Arʙidol^® appoint 200 mg 4 times / day (every 6 no) during 5 days, then – by 200 mg 1 times / week. during 4 weeks. Children aged 6 to 12 years appoint 100 mg 4 times / day (every 6 no) then – by 100 mg 1 times / week. during 4 weeks. For children from 3 to 6 years appoint 50 mg 4 times / day (every 6 no) during 5 days, then – by 50 mg 1 times / week. during 4 weeks.

To treatment of SARS adults and children over 12 years appoint 200 mg 2 times / day for 8-10 days.

As a part of complex therapy of chronic bronchitis and recurrent herpes infection adults and children over 12 years the drug is prescribed for 200 mg 4 times / day (every 6 no) during 5-7 d, then – by 200 mg 2 times / week. during 4 weeks. Children aged 6 to 12 years by 100 mg 4 times / day (every 6 no) during 5-7 d, then – by 100 mg 2 times / week. during 4 weeks. Children aged 3 to 6 years appointed 50 mg 4 times / day (every 6 no) during 5-7 d; then – by 50 mg 2 times / week. during 4 weeks.

As a part of complex therapy of acute intestinal infection rotavirus older children 12 years appoint 200 mg 4 times / day (every 6 no) during 5 d, aged from 6 to 12 years – by 100 mg 4 times / day (every 6 no) during 5 d, aged 3 to 6 years – by 50 mg 4 times / day (every 6 no) during 5 d.

Side effect

Rarely: allergic reactions.

Contraindications

- Children up to age 3 years;

- Hypersensitivity to the drug.

Pregnancy and lactation

Data on the use of Arbidol^® during pregnancy and breastfeeding is not provided.

Cautions

Effects on ability to drive vehicles and management mechanisms

The drug shows no central neurotropic activity and can be used in medical practice as a preventive measure in healthy persons of various professions, require increased attention and psychomotor speed reactions (incl. transport drivers, operators).

Overdose

An overdose of the drug is not checked.

Drug Interactions

In the appointment of other drugs adverse effects were noted.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

List B. The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life - 2 year.