Manchurian Aralia – Aralia mandshurica Rupr. and Maxim.
Small tree height of 1.5-3 m, families aralievыh (Araliaceae). The plant is widespread in the Far East, The Korean peninsula and in North China. In medicine, used the roots of Aralia, from which prepare infusion and drug Saparal.
The chemical composition of aralia
The roots of Aralia contain proteins, starch, carbohydrates, essential oils, mineral compounds, a small amount of alkaloids. From the roots of isolated triterpenoid saponins - A aralosides, And C, which are oleanolic acid glycosides (triozid and two tetraozada oleanovoy acid) and have about the same physical and chemical properties.
Pharmacological properties aralia
Herbal medicines aralia in experiments on laboratory animals have a stimulating effect on the central nervous system, better than the activity of the effect of ginseng and Eleutherococcus. In animal studies, it noted gonadotropic effect of the extract of the root of Aralia. Water extract of the roots of plants to stimulate proliferation of yeast cells.
When the pharmacological study of the roots of tincture Aralia found, stimulative effect that is manifested in the increase in locomotor activity of animals and to enhance behavioral. Besides, animals reduced the duration of sleep, caused by the introduction of barbiturates. Preparations from Aralia no significant effect on blood pressure, stimulates breathing and a few have some kardiotoniche- skim effect.
Aralia Manchu has a prophylactic and therapeutic effect in. experimental radiation sickness and adloksanovom diabetes rats. It was also established anti-stress effect of the drug.
Saparal - Medication, resulting from the roots of aralia. It consists of the sum of the triterpene oleanolic acid glycosides (A aralosides, And C). Saparal has little toxicity, its hemolytic index is relatively low, long-term use does not cause side effects and is well tolerated by the animals. By obschevozbuzhdayuschemu action Saparal close to aralia.
Experimental study of the effect on the central nervous system Saparal greatly expanded knowledge of the stimulative effect of herbal forms Aralia.
In experiments on different kinds of laboratory animals established clear awakening Saparal action in relation to the hypnotic effect of chloral hydrate and sodium barbital. As shown by a comparison of the results, antidrug effect of the drug is more pronounced during treatment with sodium barbital, which may indicate the preferential localization of the exciting effect aralosides A, B and C at the level of the subcortical regions of the brain.
A stimulative effect aralosides, B and C with electroencephalographic study of drug (both single, and with the reintroduction) characterized by distinct generalized activation reaction with a predominance in the electrophysiological parameters of the EEG, reflecting the strengthening of the process of excitation in the test cortical and subcortical brain structures, as well as a marked increase in the level of excitability, reactivity and lability of nervous elements.
In the study of the influence of the exciting Saparal for narcotic depressed background electrical activity of the brain also noted the weakening effects of electroencephalographic, caused by the introduction of chloral hydrate and barbital- sodium. This action was aimed not only at normalization of higher nervous activity and functions of nerve cells, but also on further strengthening of the processes of excitation and increased tone of the functional state of the nerve elements.
The results allow to carry Saparal CNS stimulant action of sync preferentially localized effect at the level of the reticular structure of the midbrain.
The experiments found, that the drug has a negative chronotropic and positive inotropic effect on the activity of the heart. The mechanism of this action on the heart is carried out due to the activation of stem activity centers parasympathetic innervation. Effect on Heart, According to the study vectorcardiographic, characterized by increased myocardial contractility, related, apparently, with the improvement of metabolic processes in it.
Application aralia in medicine
The infusion of the roots of aralia used in astenonevroticheskih states, posttraumatic asthenia, asthenic syndrome on the basis of chronic neurological diseases (in particular, when postgrippoznyh arachnoiditis). Side effects of the drug has no.
It noted a beneficial effect tincture aralia when expressed asthenic states in patients with post-traumatic lesions of the central nervous system and in the initial stages of cerebral arteriosclerosis. Tincture aralia improves the general health of patients, increases appetite, operability, It has a stimulating effect on the central nervous system and cardiovascular system, increases lung capacity and muscle strength.
Tincture aralia shown to patients in convalescence after severe chronic diseases, when astenodepressivnyh states, physical and mental fatigue, Impotence, gipotonii.
The drug is contraindicated with increased nervous excitability, insomnia, hypertensive disease.
Medicinal properties Saparal studied in patients with organic lesions and functional disorders of the nervous system. The drug is used to treat diseases of the peripheral nervous system, as well as for the treatment of patients with residual effects cranial trauma, functional disorders of the nervous system, with residual symptoms after circulatory disorders. All patients had expressed astenodepressivnyh or astenoipohondricheskih syndrome, some observed vascular hypotension. The criteria for efficacy are improved sleep, memory, efficiency, the disappearance of fatigue, hyperesthesia, general hyperexcitability, normalization of vascular tone.
In the treatment of patients Saparaliyev measured blood pressure, We noted the dynamics in the therapeutic and neurological status, ECG, examined blood and urine.
The therapeutic effect was observed already in the 4-day treatment "improves overall health, decreased headache and weakness. A number of patients increased blood pressure in the 1,33- 2,0 kPa (10-15 Mm Hg. Article). On the 15-20 th day of treatment, most patients disappeared or decreased headaches and heart pain, improve overall, mood, sleep and performance.
In the 10-15-day treatment systolic blood pressure increased on 1,33-4,0 kPa (10-30 Mm Hg. Art.), diastolic - to 1,33-2,67 kPa (10-20 Mm Hg. Art.). There was a positive dynamics of electrocardiographic. Formula Blood, protein composition, coagulation ability of blood did not change significantly. A urinalysis remained normal. No side effects of the drug in the treatment process and in the long term was not observed.
Patients with functional disorders of the nervous system Saparal appointed by 1 tablet (0,05 g) morning and afternoon after meal in combination with vitamins (vitamin C 0,25 g, a nicotinic acid 0,03 g, Thiamine Chloride 0,005 g, pyridoxine 0,01 g, rutin 0,1 city) and mineral salts (drugs fosfren, Phytate). Use of the drug in combination with vitamins and minerals helps to improve cellular metabolism and functional state of the central nervous system. Treatment was conducted two courses for 20-25 days each with 10-14- day intervals; 2-th treatment Saparaliyev administered at half the daily dose.
The most effective treatment was in patients with functional disorders of the nervous system, resulting from prolonged mental or physical fatigue. After treatment 50 % patients fully recovered, the rest was a significant improvement in health.
The drug is contraindicated in epilepsy, giperkinezah, hypertension, hyperexcitability. Do not appoint him in the evening (in order to avoid sleep at night).
Formulations, Dosing and Administration aralia
Tincture aralia (Tincture Araliae) (1:5) on 70 % alcohol from the roots of aralia. Assign inside of 30-40 drops to receive 2-3 times a day. Sold by prescription.
Available in bottles. Store in a dark place.
Saparal (Saparalum) appointed interior after eating 0,05 g (1 tablet) 2-3 Times a day (morning and afternoon). The course of treatment 15-30 days. After a 1-2-week break to repeat courses of treatment, assigning preparation of 0.05-0.1 g per day for 10-15 days. For preventive purposes appointed by 0.05-0.1 g per day.
Available in tablets. Store in dark glass bottles in the dry, cool, protected from light.
