ANVIFEN

Active material: aminofenilbutirovoj acid hydrochloride
When ATH: N06B
CCF: Nootropics
ICD-10 codes (testimony): F10.3, F40, F48.0, F51.2, F95, F98.0, (F) 98.5, H81, H81.0
When CSF: 02.14.01
Manufacturer: Antiviral NPO ZAO (Russia)

Pharmaceutical form, composition and packaging

Capsules hard gelatin, №3, white; contents of capsules – mix powder and/or granules white or white with a yellowish Sheen color.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, Titanium dioxide (E171), water.

10 PC. – contour cell package (1) – packs cardboard.
10 PC. – contour cell package (2) – packs cardboard.
10 PC. – contour cell package (3) – packs cardboard.
10 PC. – contour cell package (5) – packs cardboard.

Capsules hard gelatin, №3, white housing, Blue lid; contents of capsules – mix powder and/or granules white or white with a yellowish Sheen color.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, dye azorubin (E122), dye brilliant blue (E133), quinoline yellow dye (E104), Titanium dioxide (E171), water.

10 PC. – contour cell package (1) – packs cardboard.
10 PC. – contour cell package (2) – packs cardboard.
10 PC. – contour cell package (3) – packs cardboard.
10 PC. – contour cell package (5) – packs cardboard.

Capsules hard gelatin, №2, white housing, Blue lid; contents of capsules – mix powder and/or granules white or white with a yellowish Sheen color.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, dye azorubin (E122), dye brilliant blue (E133), Titanium dioxide (E171), water.

10 PC. – contour cell package (1) – packs cardboard.
10 PC. – contour cell package (2) – packs cardboard.
10 PC. – contour cell package (3) – packs cardboard.
10 PC. – contour cell package (5) – packs cardboard.

Capsules hard gelatin, №0, white housing, dark blue lid; contents of capsules – mix powder and/or granules white or white with a yellowish Sheen color.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, dye azorubin (E122), dye brilliant blue (E133), Titanium dioxide (E171), water.

10 PC. – contour cell package (1) – packs cardboard.
10 PC. – contour cell package (2) – packs cardboard.
10 PC. – contour cell package (3) – packs cardboard.
10 PC. – contour cell package (5) – packs cardboard.

Pharmacological action

Nootropics. Facilitates GABA-mediated transmission of nerve impulses in the central nervous system (direct effect on GABA ergic-receptors). Trankvilizirutee effect combined with aguirutm effect. Also has antiagregantnym, antioxidant and anti-inflammatory action of some.

Improves the functional condition of the brain due to the normalization of metabolism and its influence on cerebral blood flow (increases volume and linear speed, decreases vascular resistance, improves microcirculation, provides antiplatelet effect). Extends the latent period and shortens the duration and severity of nystagmus.

Does not affect holino- and adrenergic receptors. Decreases vazovegetativnye symptoms (incl. Headache, feeling of heaviness in the head, sleep disorders, irritability, emotional lability). In kursovom admission enhances physical and mental fitness (Attention, memory, the speed and accuracy of sensory-motor reactions).

Reduces fatigue (improves well-being, increases the interest and initiative (motivation activities)) without sedation or excitation.

Helps reduce feelings of anxiety, tension and anxiety, normalizes sleep.

The elderly it is oppression CNS, muscle-relaxing AfterEffect often missing.

Pharmacokinetics

Absorption and distribution

Absorption vыsokaya.

It penetrates into all body tissues and GEB (in brain tissue penetrates about 0.1% administered dose, and in young and elderly people to a much greater extent). Evenly distributed in the liver and kidneys.

Metabolism and excretion

It is metabolized in the liver – 80-95 %, metabolites pharmacologically inactive. Not accumulates.

Through 3 h begins to appear in the urine, However, this concentration in brain tissue is not reduced and is found within 6 no. About 5% excreted in the urine as unchanged, partly jelchew.

Testimony

-asthenic and anxious-neurotic State;

— stuttering, and enuresis in children;

— insomnia and night anxiety in elderly;

- Meniere's disease;

-Vertigo, associated with dysfunction of the vestibular Analyzer different Genesis;

-Prevention of motion sickness when kinetozah;

— in the treatment of alcohol withdrawal syndrome for cupping psychopathological and somatic disorders.

Dosage regimen

The drug is prescribed inside, after meal. A course of treatment – 2-3 of the week.

Adults and children over 14 years appoint 250-500 mg 3 times / day (the maximum daily dose 2.5 g).

Children aged 3 to 8 years appoint 50-100 mg 3 times / day; aged 8 to 14 years – by 250 mg 3 times / day. The maximum single dose in adults and children over 14 years is 750 mg, in older patients 60 years – 500 mg, in Children up to 8 years – 150 mg, in children from 8 to 14 years – 250 mg.

At alcohol withdrawal syndrome appoint 250-500 mg 3 times per day and night 750 mg, with a gradual decrease in the daily dose to normal for adults.

To treatment for Vertigo in vestibular dysfunctions and Meniere's disease the drug is prescribed for 250 mg 3 times / day for 14 days.

To Prevention of motion sickness appointed 250-500 mg dose of 1 hours before the anticipated start of pitching or when the first symptoms of seasickness. Action Anvifena^® increases with increasing doses of the drug. Upon occurrence of the expressed manifestation of seasickness (vomiting, etc.) appointment of Anvifena^® ineffective even at doses 750-1000 mg.

Side effect

CNS: drowsiness, increased irritability, excitation, alarm, dizziness, headache (When the first techniques).

Other: nausea, allergic reactions.

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

- Children up to age 3 years;

- Hypersensitivity to the drug.

FROM caution should designate product if erosivno-ulcerative lesions of STOMACH, hepatic insufficiency.

Pregnancy and lactation

Application of Anvifen^® contraindicated during pregnancy and lactation.

Cautions

With long-term use should be periodically monitored the liver and picture peripheral blood.

Effects on ability to drive vehicles and management mechanisms

During the period of administration of the drug should refrain from potentially hazardous activities, requiring a high concentration.

Overdose

Symptoms: severe drowsiness, nausea, vomiting, fatty liver (reception more 7 g), eozinofilija, decrease in blood pressure, impairment of renal function.

Treatment: gastric lavage, reception activated carbons symptomatic therapy and.

Drug Interactions

Anfiven^® While applying extends and enhances the effect of somniferous drugs, Opioid analgesics, neuroleptics, antiparkinsonian and anticonvulsants.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, protected from light, inaccessible to children at temperature not exceeding 25 ° C. Shelf life -3 year.