Antithrombin III

When ATH:
B01AB02

Characteristic.

The lyophilized powder of antithrombin III purified human plasma. Solutions for injection are pH 6,0-7,5.

Pharmacological action.
Antykoahulyantnoe.

Application.

Hereditary antithrombin III deficiency, DIC.

Contraindications.

Hypersensitivity, childhood (Safety and efficacy have not been established).

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Dizziness, difficulty breathing or shortness of breath, nausea, an unpleasant taste in the mouth, chills, gripes, chest pain, blurring of vision, fullness bowel, hives, fever, Sweating, hematoma.

Dosing and Administration.

B /, dose, providing 120% normal levels (12,5 mg / l) AT-III, considering, what 1 МЕ/кг увеличивает плазменный уровень AT-III на 1,4%; maintenance dose - 60% от начальной каждые 24 ч для обеспечения уровня AT-III при длительной терапии в пределах 80–120% нормы. Максимальная дневная доза не более 3000 ME. Doses in international units calculated according to the formula (ME = (требуемый уровень АТ-III — исходный уровень) x body weight in kg / 1,4).

Precautions.

It is recommended to reduce the dose of heparin when combined with AT-III (prevention of bleeding). The gestation period is prescribed only in case of emergency (Safety has not been established).

Cautions.

The diagnosis of hereditary AT-III deficiency should be completely confirmed history of the patient and his relatives.