Antigrippin Maximum (Powder)

Active material: combined preparation
When ATH: J05AX
CCF: Preparation for causal and symptomatic treatment of respiratory viral infections
ICD-10 codes (testimony): J06.9, J10, R50
When CSF: 03.02.01.03.01
Manufacturer: Antiviral NPO ZAO (Russia)

Pharmaceutical form, composition and packaging

◊ Capsules two species.

P hard gelatin capsules, of blue color, size №0; contents of capsules – a mixture of powder and / or granules of white or white with Valium or pinkish tint, granules of irregular shape, different size, allowed the presence of lumps.

Excipients: gelatinized starch, lactose, magnesium stearate, colloidal silicon dioxide.

Ingredients of the capsule shell: gelatin, water, sodium lauryl, methylparaben, propyl, Dyes (blue V, karmoizin, Titanium dioxide).

F Hard gelatin capsules, of red color, size №0; contents of capsules – a mixture of powder and / or granules yellow with a greenish tinge and white, irregularly shaped granules of different sizes, allowed the presence of lumps.

Excipients: potato starch, magnesium stearate.

Ingredients of the capsule shell: gelatin, water, sodium lauryl, methylparaben, propyl, Dyes (poncho 4R, blue V, Titanium dioxide).

10 PC. (5 caps. And P 5 caps. P) – packings Valium planimetric (1) – packs cardboard.
10 PC. (5 caps. And P 5 caps. P) – packings Valium planimetric (2) – packs cardboard.
20 PC. (10 caps. And P 10 caps. P) – packings Valium planimetric (1) – packs cardboard.
20 PC. (10 caps. P in a separate package Valium planimetric (1) and 10 caps. P in separate packings Valium planimetric (1)) – packs cardboard.

◊ Powder for oral solution [lemon, lemon with honey, crimson, blackcurrant] as a mixture of granules nearly white powder with a yellowish-greenish, with a characteristic odor; prepared solution is colorless or yellowish tinge, slightly cloudy, with a characteristic odor (Lemon, lemon with honey, raspberries, blackcurrant), It allowed the presence of undissolved particles yellow.

Excipients: Aspartame, gipromelloza, colloidal silicon dioxide, lactose, food flavoring (lemon, lemon with honey, crimson, blackcurrant).

5 g – packets of the composite material (3) – packs cardboard.
5 g – packets of the composite material (6) – packs cardboard.
5 g – packets of the composite material (8) – packs cardboard.
5 g – packets of the composite material (12) – packs cardboard.
5 g – packets of the composite material (24) – packs cardboard.

Pharmacological action

Combined with the antiviral drug, interferonogenic, antipyretic, anti-inflammatory, analgesic, anti-allergic and angioprotective action.

Paracetamol obladaet zharoponizhayushtim, analgesic and anti-inflammatory action.

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, normalizes capillary permeability, blood clotting, tissue regeneration, activates the immune system.

Calcium gluconate prevents the development of increased permeability and fragility of blood vessels, which cause hemorrhagic processes of the flu and SARS, and restores the capillary circulation and has anti-allergic effect (mechanism has unclear). Recommended for use in combination with antihistamines for treating allergic reactions.

Rimantadin – antiviral agent, active against influenza A (especially A2). Reduces toxic manifestations, caused by influenza viruses and viruses of other types of, SARS is caused by various. It has also interferonogenic properties, increases the total content of interferon in the blood (especially interferon gamma). It enhances the effectiveness of the drug in viral infections of the respiratory tract.

Rutozid – angioprotektor. By eliminating the increased capillary permeability, reducing its swelling and inflammation, strengthens the vascular wall. It has antiplatelet effect and increases the degree of deformation of the red blood cells.

Loratadine – gistaminovыh blocker H₁-receptors, It has anti-allergic effect, prevents the development of edema, associated with the release of histamine.

Pharmacokinetics

Data on the pharmacokinetics Antigrippin Maximum not provided.

Testimony

Etiotropic and symptomatic treatment of adults and children over 12 years:

- The flu;

- At SARS;

- With fevers due to viral respiratory diseases.

Dosage regimen

Adults and children over 12 years the drug should be taken orally after a meal; Capsules should be taken with water.

Antigrippin High in capsules apply for 1 P capsule blue and 1 P red capsule 2-3 times / day until symptoms of the disease.

Antigrippin Maximum form powder for oral solution apply for 1 paketiku 2-3 times / day until symptoms of the disease. Preparation of the solution: contents 1 Dissolve sachet in 1 cup of boiled hot water. Eat hot, previously having stirred.

The duration of treatment is 3-5 days (no more 5 days). If during the 3 days after the start of the drug feel better is not observed, should stop taking the drug and seek medical advice.

Side effect

CNS: rarely – hypererethism, tremor, giperkineziya.

From the digestive system: perhaps (With prolonged use of a 7 days) – damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

From the hematopoietic system: perhaps (With prolonged use of a 7 days) – agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

Allergic reactions: rarely – skin rash, itch, hives.

In the case of the onset of symptoms of side effects, stop taking the drug and seek medical advice.

Contraindications

- Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;

- Gastro-intestinal bleeding;

- Hemophilia;

- Gyemorragichyeskii diatyez;

- Gipoprotrombinemii;

- Portal hypertension;

- Vitamin K deficiency;

- Thyrotoxicosis;

- Acute and worsening of chronic kidney disease (incl. acute glomerulonephritis, acute pyelonephritis);

- Renal failure;

- Acute or exacerbation of chronic liver disease (incl. acute hepatitis);

- Alcoholism;

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

FROM caution use in patients with epilepsy and cerebral atherosclerosis.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

Long-term use – no more 5 days.

With prolonged use (more 7 days) possible exacerbation of chronic comorbidities, in elderly patients with hypertension increases the risk of hemorrhagic stroke (by members of the drug rimantadine hydrochloride).

The drug should not be used in the presence of metastatic tumors.

Use in Pediatrics

The drug should not be given children under the age of 12 years.

Overdose

Symptoms: first 24 h are possible pallor, nausea, vomiting, epigastric pain, tremor, drowsiness, tachycardia, increased levels of bilirubin in the blood, metabolic disorders, exacerbation of underlying chronic diseases.

Treatment: should cause an artificial vomiting, wash out the stomach, appoint adsorbents, spend symptomatic therapy. If overdose, seek medical advice.

Drug Interactions

If necessary, the simultaneous application of maximum Antigrippin with other drugs should consult a doctor.

Not recommended simultaneous application Antigrippin Maximum with anticoagulants, GCS, hepatotoxic agents, ʙarʙituratami, anticonvulsants, rifampicin, alcohol (ethanol).

While the use of metoclopramide may increase absorption of the active drug substance.

In an application with indirect anticoagulants coumarin derivatives may develop a small gipoprotrombinemii.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.