ANTIFLU (Powder)

Active material: chlorphenamine maleate, Paracetamol, Phenylephrine
When ATH: N02BE51
CCF: The drug for the symptomatic treatment of acute respiratory diseases
ICD-10 codes (testimony): J00, J06.9, J10, R50
When CSF: 03.02.01.03
Manufacturer: SAGMEL, Inc. (United States)

Pharmaceutical form, composition and packaging

◊ Powder for oral solution mixtures of crystalline white or yellow powder with weak smell of lemon.

Excipients: vitamin C, lemon acid, silicon dioxide, natural lemon flavor, sodium citrate trehosnovnoj, starch, sucrose, Titanium dioxide, calcium phosphate fodder, dye FD&C yellow 10, dye FD&C yellow 6.

17 г – пакетики из ламинированной фольги (5) – пачки картонные.

Pharmacological action

Combined preparation. Paracetamol okazыvaet analygeziruyushtee, antipyretic and anti-inflammatory action of weakly expressed.

Фенилэфрина гидрохлорид – альфа-адреномиметик – оказывает сосудосуживающее действие, It reduces swelling and congestion of the nasal mucosa and sinuses.

Хлорфенирамина малеат – блокатор гистаминовых H₁-рецепторов – оказывает противоаллергическое действие, reduces the severity of the local manifestations of exudative, eliminates tearing, itchy eyes and nose

Pharmacokinetics

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Testimony

Symptomatic treatment of colds, Flu, SARS:

- Feverish syndrome;

- Pain;

- Rhinorrhea.

Dosage regimen

Inside. Adults and children over 12 years appointed: by 1 paketiku every 4 no, but not more 4 sachets per day.

Before taking the contents 1 paketika dissolve in a glass of hot water.

Duration of treatment is not more 3 days.

The patient must notify, In the absence of adequate therapeutic effect, There is a high temperature, which is based on a background of treatment 3 days, as well as the appearance of new symptoms should immediately consult a doctor.

Side effect

There are allergic reactions (rash, itch, hives, angioedema), hypererethism (especially in children), sleep disturbance, drowsiness, decrease in the rate of psychomotor reactions, feeling tired, nausea, vomiting, stomachache, heartbeat, increased blood pressure, dizziness, midriaz, Parez akkomodacii, increased intraocular pressure, dry mouth, urinary retention,.

Considering availability of paracetamol: редко – нарушения со стороны системы кроветворения (anemia, thrombocytopenia, leukopenia, agranulocytosis); при длительном приеме высоких доз – возможны гепатотоксическое и нефротоксическое действие, gemoliticheskaya anemia, metgemoglobinemiâ, pancytopenia.

Contraindications

- Hypersensitivity to the individual components of the drug;

- Pregnancy;

- Breastfeeding;

- Portal hypertension;

- Alcoholism;

- Renal failure;

- Deficiency of glucose-6-fosfatdegidrogenazы.

Do not use in children under 12 years.

FROM caution used in hypertension, severe cardiovascular diseases, diabetes, asthma, chronic obstructive pulmonary disease, thyrotoxicosis, pheochromocytoma, angle-closure glaucoma, severe liver or kidney disease, difficulty urinating in prostate cancer, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rothera.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

During the period of treatment should refrain from drinking alcohol, hypnotics and anxiolytics (trankvilizatorы) drugs; avoid driving vehicles, using machinery or other potentially dangerous activities.

Do not be taken with other drugs, soderzhashtimi paracetamol.

If symptoms do not resolve within 3-5 days, consult a doctor.

Overdose

Tied, usually paracetamol, manifested after taking over 10-15 g last.

There are: pale skin, anorexia, nausea, vomiting, epigastric pain, increase in liver transaminases, increased prothrombin time, hepatotoxic and nephrotoxic action, in severe cases develop liver failure, encephalopathy and coma.

Treatment: gastric lavage, activated charcoal in the first 6 no, introduction of donators of SH-groups and precursors of glutathione synthesis by methionine 8-9 hours after the overdose and N-acetylcysteine ​​after 12 no.

Drug Interactions

It is recommended to refrain from taking the drug while taking MAO inhibitors.

The risk of hepatotoxicity of paracetamol is increased with concomitant administration of barbiturates, difenina, karʙamazepina, rifampicin, AZT and other inducers of microsomal liver enzymes.

It enhances the effect of sedatives, ethanol. Ethanol increases the sedative effect of chlorpheniramine.

Antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

Store in a dry, reach of children, at a temperature from 15 ° to 25 ° C.. Shelf life - 3 year. Do not use beyond the expiration date.