Angioedema (Angioedema) – treatment of disease. Symptoms and prevention of angioedema disease

Angioedema – What is this disease? Angioedema-acute local allergic swelling of the mucous membrane, skin, subcutaneous tissue.

Angioedema: the cause of the

Cause allergic angioneuroticeski pain-allergen exposure (medicines, products, insect bites, animal dander) in conjunction with the inadequate reaction of the organism to it. Does the release of large amounts of histamine, provoking local and distributed development of edema.

The cause of congenital angioneuroticeski pain is a mutation in the gene C1NH, that leads to the deficiency of C1-Inhibitor of complement. Deficiency of this enzyme leads to an uncontrolled release of biologically active substances (biological amines), Histamine in particular, prostaglandins, kinins are substances, that tissue swelling.

Angioedema: symptoms

Attacks of allergic edema is characterized by difficulty breathing due to edema of the Mucosa, submucous membranes of the larynx. The voice becomes ohriplym, breathing is noisy, dry appears barking cough. As a result of a long choking person blush, nasolabial triangle and pale lips. Oteke the mucous membrane of the gastrointestinal tract are having nausea, vomiting, rumbling and abdominal pain. In most cases, the swelling disappears within three days. Angioedema can be combined with red or pink spots zudjashhimi (hives).

Angioedema: diagnostics

When allergic form:

• general blood analysis, Urine;
• skin tests with allergens;
• study of the complement system;
• the study found.

In the hereditary form:

• search for mutations in the gene S1NH;
• study level C4 of the complement system component, C1-Inhibitor (substances, who participate in the development of edema in the hereditary form);
• the survey of relatives of the patient to determine the hereditary nature of illness.

Angioedema: types of disease

Depending on the specifics of edema, the reasons for its development secrete form angioneuroticeski pain:

Allergic-called the action of allergens, can accompany food allergy, do not ignore nasal catarrh, krapivnice, other allergic diseases or manifest themselves. Allergic angioedema can develop as a result of exposure to certain medications, that lead to increased release of gistaminov (Angiotensin-converting enzyme inhibitors, anti-inflammatory drugs), food additives or products.

Hereditary (psevdoallergicheskij) -develops as a consequence of innate complement system. Such angioedema occurs for no apparent reason or under the influence of changing temperature conditions, other physical stimuli.

Angioedema: patient actions

Angioedema is a life-threatening condition, the poem when it occurs should seek medical advice.

Angioedema treatment

To determine the presence of oedema of larynx. When, If there is one, and breathing is difficult, There is a need to conduct intubation or traheostomiju. Also requires control of parameters of work of cardiovascular system: heart rate, blood pressure.

Medicamental therapy in hereditary form:

• introduction of fresh frozen plasma, which is composed of enzymes, including C1-Inhibitor, lack of which leads to the development of angioneuroticeski pain;
• mochegonne drugs reduce the severity of edema;
• antifibrinolitiki-drugs, violate the formation of kinins, causing tissue swelling;
• hormonal means (steroids).

When allergic form:

• antihistamines (antiallergic) preparations;
• Diuretic (diuretics) to reduce the severity of edema;
• hormonal drugs (steroids).

Angioedema: complications

Laryngeal edema can lead to disruption of breathing until suffocation and death.

Swelling of the mucous membrane of the gastrointestinal tract leads to severe pain in the abdomen, undue intervention on this matter.

When distributing the swelling of brain tissue, meninges are having neurological disorders (afazija, death, hemiplegia, etc.).

Lesions of organs of the urogenital system may be accompanied by symptoms of acute cystitis, lead to the development of acute urinary retention.

Angioedema: prevention

When allergic form:

• refraining from taking some medicines, likely to cause heart attack (Angiotensin-converting enzyme inhibitors, anti-inflammatory drugs, angiotensin II receptor antagonists);
• exclusion of surgical interventions, other injuries, stressful situations, colds;
• compliance with the hypoallergenic diets (exception identified or other vysokoallergennyh products (seafood, nuts, etc.).

In the hereditary form:

• refraining from taking medication, likely to cause heart attack (Angiotensin-converting enzyme inhibitors, anti-inflammatory drugs, angiotensin II receptor antagonists);
• exclusion of surgical interventions, other injuries, stressful situations, colds.