Amorphous suffrutescent – Amorpha fruticosaL.
Decorative perennial shrub 1.5 2 m, leguminous (Leguminosae). In wild-growing plant species found in North America. For medical purposes, they prepare fruits (seed).
The chemical composition of amorphous semishrub
The seeds contain amorphous suffrutescent rotenoidnye glycosides, the main of them - amorfin, fissionable during hydrolysis to aglikonamorfigenin, glucose and arabinose.
The pharmacological properties of amorphous suffrutescent
The biological activity of fruit plants is determined by the pharmacological properties of the glycoside amorfina, which has mostly neurotropic action. In experiments on different animals marked calming effect amorfina. Glycoside reduces the effect of convulsive analeptikov (kamfora, korazol, strychnine) and potentiates the effect of hypnotics.
Amorfin inhibits conditioned reflex activity of animals, resulting in an increase in the latent period of the reflex reactions and lowering of conditioned reflexes. These effects are confirmed in an experiment to study the influence of the drug on the electrical activity of the cerebral cortex. Amorfin weakens the bioelectric activity of the cerebral cortex, suppressing high-frequency rhythms and more increasing number of low-frequency waves. Besides, amorfin possess cardiotonic properties, exerting a positive inotropic and negative chronotropic effects on the heart.
Application of amorphous suffrutescent medicine
On the basis of the glycoside amorfina was established drug frutitsin, which was used as a sedative in neurotic conditions of different – origin (neuroses of the cardiovascular system, vasoneurosis, neurogenic paroxysmal tachycardia).
Contraindications and side effects were not observed.
Currently, due to the introduction of the practice of more effective drugs frutitsin excluded from the range of medicines.
