Aminocaproic acid
When ATH:
B02AA01
Characteristic.
An inhibitor of fibrinolysis.
Colourless crystals or a white crystalline powder, odorless and tasteless. Easily soluble in water, very little is soluble in methanol, practically insoluble in ethanol and chloroform. Molecular weight 131,7.
Pharmacological action.
Hemostatic.
Application.
Bleeding (giperfiʙrinoliz, Hypo- and afibrinogenemia). Bleeding in surgical interventions on the organs, rich activators of fibrinolysis (lungs, thyroid, stomach, Cervix, prostate). Diseases of internal organs with hemorrhagic syndrome; premature detachment of the placenta, abortion complications. To prevent secondary hypofibrinogenemia when massive transfusion of stored blood.
Contraindications.
Hypersensitivity, hypercoagulable states with a tendency to thrombosis and embolism, chronic renal failure, cerebrovascular accident, DIC, pregnancy.
Restrictions apply.
Hypotension, valvular heart disease, hematuria, bleeding from the upper urinary tract of unknown etiology, hepatic failure, impairment of renal function.
Pregnancy and breast-feeding.
Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)
Side effects.
Raʙdomioliz, mioglobinuriâ, acute renal failure, subendocardial hemorrhage, nausea, diarrhea, convulsions, decrease in blood pressure, orthostatic hypotension, headache, dizziness, noise in ears, nasal congestion, skin rashes.
Cooperation.
Effect reduce anticoagulants (direct, Indirect), antiagregantы.
Dosing and Administration.
B / drip, inside, locally. Adults: in/in with acute bleeding during 1 h impose 4-5, 2011, dissolved in 250 ml 0,9% sodium chloride solution; supportive therapy is on 1 g (in 50 ml) every hour until it stops bleeding, but not more 8 no.
Inside (washed down with sweet water) appointed 5 g, then - on 1 g every hour during 8 no (no more) until it stops bleeding. The average daily intake is 10-18 g, The maximum daily dose - 24 g. Children at the rate of 50-100 mg/kg.
Locally: bleeding surface irrigate chilled 5% solution (50-200 ml), or applied to the bleeding surface in 1-2 layers moistened wipes aseptically.
Precautions.
In the appointment of aminocaproic acid is necessary to control the fibrinolytic activity of blood and fibrinogen.
There are reports of inappropriate use women to prevent elevated blood loss during childbirth due to the possibility of thromboembolic complications in the postpartum period.
