AMIKSIN

3,181 5 minutes read

Active material: Tiloron
When ATH: J05AX
CCF: The antiviral and immunomodulatory drugs. Inducer of interferon synthesis
ICD-10 codes (testimony): A15, A56.0, A56.1, A56.4, A60, B00, B02, B15, B16, B17.1, B18.1, B18.2, B25, G04, G35, J06.9, J10, J16.0
When CSF: 09.01.05.02
Manufacturer: OAO Pharmstandard-Tomskhimfarm (Russia)

Pharmaceutical form, composition and packaging

Pills, Film-coated orange, round, lenticular; of presentations – orange, Slight blotches of orange or white.

	1 tab.
tiloron (tilaksin)	60 mg

Excipients: potato starch, microcrystalline cellulose, povidone (Kollidon 30), calcium stearate, Croscarmellose sodium (primelloza).

The composition of the shell: gipromelloza (hydroxypropyl), Titanium dioxide, macrogol 4000 (polyethylene glycol 4000), polysorbate 80 (Tween 80), quinoline yellow (E104), sikovit yellow-orange 85 (E110).

6 PC. – packings Valium planimetric (1) – packs cardboard.
6 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
6 PC. – plastic jars (1) – packs cardboard.
10 PC. – plastic jars (1) – packs cardboard.
20 PC. – plastic jars (1) – packs cardboard.

◊ Pills, Film-coated orange, round, lenticular; of presentations – orange, Slight blotches of orange or white.

	1 tab.
tiloron (tilaksin)	125 mg

Excipients: potato starch, microcrystalline cellulose, povidone (Kollidon 30), calcium stearate, Croscarmellose sodium (primelloza).

Pharmacological action

The antiviral and immunomodulatory drugs. The low molecular weight synthetic interferon inducer, stimulating the body's interferon alpha, beta, gamma. The main structures, producing interferon in response to tilorona, are the cells of the intestinal epithelium, gepatocitы, T lymphocytes, neutrophils and granulocytes. After taking the drug inside a maximum production of interferon is defined in the sequence gut-liver-blood through 4-24 no. Amiksin^® It has immunomodulatory and antiviral effect.

In human leukocytes induces the synthesis of interferon. It stimulates bone marrow stem cells, dose-dependent increases antibody, reduces the degree of immunosuppression, restores ratio T-suppressor and T-helper cells. Effective with various viral infections (incl. caused by influenza viruses, other pathogens of acute respiratory viral infections, hepatitis, Herpes). The mechanism of antiviral action due to inhibition of translation of virus-specific proteins in infected cells, resulting in suppressed reproduction of viruses.

Pharmacokinetics

Absorption

After taking the drug inside tilorona is rapidly absorbed from the gastrointestinal tract. Bioavailability is about 60%.

Distribution

The binding to plasma proteins – about 80%.

Metabolism and excretion

Tilorona no biotransformation and accumulates in the body. Displayed virtually unchanged in the feces (about 70%) and urine (about 9%). T_1/2 is 48 no.

Testimony

In adults,

- For the prevention and treatment of influenza and SARS;

- For the treatment of viral hepatitis A, And C;

- For the treatment of herpes infections;

- For the treatment of cytomegalovirus infection;

- In the complex treatment of allergic and viral encephalomyelitis (incl. multiple sclerosis, leykoentsefality, uveoéncefality);

- In the complex treatment of urogenital and respiratory chlamydia;

- In the complex treatment of pulmonary tuberculosis.

In children older than 7 years

- For the treatment of influenza and SARS.

Dosage regimen

The drug is taken orally after meal.

In Adult to non-specific prevention of hepatitis A the drug is prescribed in a dose 125 mg 1 once a week for 6 weeks. Kursovaya dose – 750 mg (6 tab.).

At the treatment of viral hepatitis A dose on the first day of 125 mg 2 times / day, then go to the reception 125 mg after 48 no. A course of treatment – 1.25 g (10 tab.).

At treatment of acute hepatitis B in the initial phase of treatment in the first and second day dose is 125 mg / day, and then 125 mg after 48 no. A course of treatment – 2 g (16 tab.).

At protracted course of hepatitis B the first day dose is 125 mg 2 times / day, then 125 mg after 48 no. Kursovaya dose – 2.5 g (20 tab.).

At chronic hepatitis B in the initial phase of treatment the total dose is 2.5 g (20 tab.). First 2 daily dose of the day 250 mg, then go to the reception 125 mg after 48 no. In the continuation phase of treatment the total dose is 1.25 g (10 tab.) to 2.5 g (20 tab.), while the drug is prescribed in a dose 125 mg per week. Kursovaya dose Amiksin^® It varies between 3.75 to 5 g, the duration of treatment is 3.5-6 months depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

At Acute hepatitis C the first and second day of treatment Amiksin^® administered at a dose of 125 mg / day, then 125 mg after 48 no. Kursovaya dose – 2.5 g (20 tab.).

At chronic hepatitis C in the initial phase of treatment the total dose is 2.5 g (20 tab.). First 2 day take medication at a dose of 250 mg / day, then 125 mg after 48 no. In the continuation phase of treatment the total dose is 2.5 g (20 tab.), while the drug is prescribed in a dose 125 mg per week. Kursovaya dose Amiksin^® – 5 g (40 tab.), the duration of treatment is 6 months depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

At complex therapy of infections neyrovirusnyh – by 125-250 mg / day in the first two days of treatment, then 125 mg after 48 no. Dose set individually, the duration of treatment is 3-4 of the week.

To treatment of influenza and other acute respiratory viral infections first 2 days of illness Amiksin^® administered at a dose of 125 mg / day, then 125 mg after 48 no. Kursovaya dose – 750 mg (6 tab.).

To prevention of influenza and SARS Amiksin^® administered at a dose of 125 mg 1 once a week for 6 weeks. Kursovaya dose – 750 mg (6 tab.).

To Treatment of herpes, cytomegalovirus infection the first dose 2 days of 125 mg, then take the 125 mg after 48 no. Heading dose of 1.25-2.5 g (10-20 tab.).

At urogenital and respiratory chlamydia Amiksin^® administered at a dose of 125 mg / day during the first 2 days, then 125 mg after 48 no. Kursovaya dose – 1.25 g (10 tab.).

At complex treatment of pulmonary tuberculosis first 2 day medication is prescribed 250 mg / day, then 125 mg after 48 no. Kursovaya dose – 2.5 g (20 tab.).

Children over 7 years at uncomplicated forms of influenza or other acute respiratory viral infections the drug is prescribed in a dose 60 mg (1 tab.) 1 times / day after meals for 1 st, 2-st and 4th day from the treatment beginning. Kursovaya dose – 180 mg (3 tab.).

At development of complications influenza and other acute respiratory viral infections drug taking 60 mg 1 time / day on the 1st, 2-and, 4-and, 6-day from the treatment beginning. Kursovaya dose – 240 mg (4 tab.).

Side effect

From the digestive system: Possible symptoms of dyspepsia.

Other: possible short-term fever, allergic reactions.

Contraindications

- Pregnancy;

- Breastfeeding;

- Children up to age 7 years;

- Hypersensitivity to the drug.

Pregnancy and lactation

Amiksin^® contraindicated during pregnancy and breastfeeding.

Cautions

Amiksin^® compatible with antibiotics and traditional means of treating viral and bacterial infections.

Overdose

So far, cases of drug overdose Amiksin^® unknown.

Drug Interactions

Clinically significant drug interactions Amiksina^® antibiotic agents and conventional treatment of viral and bacterial infections are not identified.

Conditions of supply of pharmacies

Drug in tablet form 60 mg by prescription.

Drug in tablet form 125 mg is approved for use as a means of non-prescription.

Conditions and terms

List B. The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 30 ° C. Shelf life – 3 year.

Vladimir Andreevich Didenko

3,181 5 minutes read