Albendazol

When ATH:
P02CA03

Characteristic.

Anthelmintics broad spectrum. White or off-white powder. Soluble in dimethylsulfoxide, strong acids and alkalis, slightly soluble in methanol, xloroforme, acetate ester, practically insoluble in water. Molecular weight 265,34.

Pharmacological action.
Protivoparazitarnoe, anthelminthic.

Application.

Nejrocisticerkoz, caused by the larval form of the pork tapeworm (Blindfold seat); hydatid disease of the liver, light, peritoneum, caused by the larval form of the dog tapeworm (Echinococcus granulosus). Nematodozы: askaridoz, tryhotsefalez, ankylostomydoz, эnterobyoz, strongiloidoz, opisthorchiasis, giardiasis, mykrosporydyoz. Mixed helminthiasis. As an adjunct to surgical treatment of cysts ehinokokkoznyh.

Contraindications.

Hypersensitivity (incl. other benzimidazole derivatives), pregnancy, breast-feeding, Children up to age 6 years (security is not defined).

Restrictions apply.

Inhibition of bone marrow hematopoiesis, hepatic failure, cirrhosis of the liver, cysticercosis involving the retina.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

From the nervous system and sensory organs: headache, dizziness, meningeal symptoms.

From the digestive tract: abdominal pain, nausea, vomiting, increased ALT, IS, Alkaline phosphatase.

Allergic reactions: skin rash, itch.

Other: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia, fever, increased blood pressure, impairment of renal function, acute renal failure, alopecia.

Cooperation.

Dexamethasone and cimetidine uvelichivayut kontsentratsiyu albendazole sulyfoksida in Resurrection.

Overdose.

Treatment: symptomatic, gastric lavage, Activated carbon.

Dosing and Administration.

Inside. Dose set individually, depending on the helminth species and body weight of the patient; neurocysticercosis and hydatid disease: patients with a body weight 60 kg and more 400 mg 2 once a day, less 60 kg - 15 mg / kg / day 2 admission; The maximum daily dose - 800 mg; a course of treatment: When nejrocisticerkoze-8-30 days, When jehinokokkoze- 3 cycle 28 days 14 day break between cycles.

Precautions.

To use caution in disorders of the liver (before and during treatment regularly monitor its function). It is recommended to monitor blood cell composition; in the event of leukopenia discontinue therapy. In women of childbearing age before treatment is carried out in the absence of pregnancy test. During therapy required reliable contraception.

When neurocysticercosis with eye disease before treatment is necessary to study the retina (the risk of worsening its pathology).